Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2556263..2556939 Replicon chromosome
Accession NZ_CP074073
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KF946_RS12250 Protein ID WP_153850214.1
Coordinates 2556263..2556712 (-) Length 150 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KF946_RS12255 Protein ID WP_153850213.1
Coordinates 2556709..2556939 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF946_RS12210 (KF946_12195) 2551339..2551986 - 648 WP_153850221.1 hypothetical protein -
KF946_RS12215 (KF946_12200) 2552113..2552436 - 324 WP_153850220.1 HigA family addiction module antitoxin -
KF946_RS12220 (KF946_12205) 2552448..2552741 - 294 WP_153850219.1 type II toxin-antitoxin system RelE/ParE family toxin -
KF946_RS12225 (KF946_12210) 2552944..2554224 + 1281 WP_153850218.1 anti-phage deoxyguanosine triphosphatase -
KF946_RS12230 (KF946_12215) 2554227..2554934 + 708 WP_153850217.1 ZIP family metal transporter -
KF946_RS12235 (KF946_12220) 2554931..2555536 - 606 WP_153850216.1 hypothetical protein -
KF946_RS12240 (KF946_12225) 2555639..2555911 + 273 WP_114982302.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
KF946_RS12245 (KF946_12230) 2555898..2556239 + 342 WP_153850215.1 type II toxin-antitoxin system RelE/ParE family toxin -
KF946_RS12250 (KF946_12235) 2556263..2556712 - 450 WP_153850214.1 type II toxin-antitoxin system VapC family toxin Toxin
KF946_RS12255 (KF946_12240) 2556709..2556939 - 231 WP_153850213.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KF946_RS12260 (KF946_12245) 2557066..2557722 + 657 WP_110013507.1 epoxyqueuosine reductase QueH -
KF946_RS12265 (KF946_12250) 2557800..2559950 - 2151 WP_153850212.1 TonB-dependent siderophore receptor -
KF946_RS12270 (KF946_12255) 2560023..2560493 - 471 WP_153850211.1 hypothetical protein -
KF946_RS12275 (KF946_12260) 2560493..2561638 - 1146 WP_153850210.1 PepSY-associated TM helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 150 a.a.        Molecular weight: 17012.36 Da        Isoelectric Point: 6.9566

>T201334 WP_153850214.1 NZ_CP074073:c2556712-2556263 [Idiomarina loihiensis]
MNLRYMLDTNICIYIMKNRPAYLAPIFDEHSRELCISSVTVMELQYGVENSQQRTTNADKLDSFLARLKILNYDTDAAYH
TALIRHKLKQQGTPIGPYDQMIAGHARCHGLTVVTNNTGEFERVPGLITENWLQQPPQSSINEPTPAYR

Download         Length: 450 bp

>T201334 NZ_CP098338:c2823495-2822173 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8676.68 Da        Isoelectric Point: 4.3575

>AT201334 WP_153850213.1 NZ_CP074073:c2556939-2556709 [Idiomarina loihiensis]
MTKTSLFKSNKTQAVRLPKDVAFSEDVKEVEVLVVGESRIITPAKTSWASWFNGEPTSDDFMVEREQPEEQERDSL

Download         Length: 231 bp

>AT201334 NZ_CP098338:c2823761-2823495 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References