Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2126114..2126624 Replicon chromosome
Accession NZ_CP074073
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name relB Uniprot ID Q5R151
Locus tag KF946_RS10215 Protein ID WP_011233548.1
Coordinates 2126114..2126377 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q5QUM2
Locus tag KF946_RS10220 Protein ID WP_011233547.1
Coordinates 2126370..2126624 (-) Length 85 a.a.

Genomic Context

KF946_RS10190KF946_RS10185KF946_RS10195KF946_RS10200KF946_RS10205KF946_RS10210KF946_RS10215KF946_RS10220KF946_RS10225KF946_RS10230KF946_RS10235KF946_RS10240KF946_RS10245KF946_RS10250KF946_RS10255
Location: 2122844..2123668 (825 bp)
Type: Others
Protein ID: WP_153849518.1
Location: 2121614..2122726 (1113 bp)
Type: Others
Protein ID: WP_153849519.1
Location: 2123752..2124306 (555 bp)
Type: Others
Protein ID: WP_153849517.1
Location: 2124347..2124727 (381 bp)
Type: Others
Protein ID: WP_153849516.1
Location: 2124783..2125337 (555 bp)
Type: Others
Protein ID: WP_153849515.1
Location: 2125427..2125918 (492 bp)
Type: Others
Protein ID: WP_255801528.1
Location: 2126114..2126377 (264 bp)
Type: Toxin
Protein ID: WP_011233548.1
Location: 2126370..2126624 (255 bp)
Type: Antitoxin
Protein ID: WP_011233547.1
Location: 2126727..2127272 (546 bp)
Type: Others
Protein ID: WP_153849513.1
Location: 2127350..2127832 (483 bp)
Type: Others
Protein ID: WP_153849512.1
Location: 2127848..2128225 (378 bp)
Type: Others
Protein ID: WP_153849511.1
Location: 2128235..2128651 (417 bp)
Type: Others
Protein ID: WP_153849510.1
Location: 2128755..2129474 (720 bp)
Type: Others
Protein ID: WP_153849509.1
Location: 2129549..2130931 (1383 bp)
Type: Others
Protein ID: WP_153849508.1
Location: 2131080..2131565 (486 bp)
Type: Others
Protein ID: WP_153849507.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KF946_RS10185 (KF946_10175)2121614..2122726-1113WP_153849519.1DUF4241 domain-containing protein-
KF946_RS10190 (KF946_10180)2122844..2123668+825WP_153849518.1hypothetical protein-
KF946_RS10195 (KF946_10185)2123752..2124306-555WP_153849517.1YaeQ family protein-
KF946_RS10200 (KF946_10190)2124347..2124727-381WP_153849516.1hypothetical protein-
KF946_RS10205 (KF946_10195)2124783..2125337-555WP_153849515.1hypothetical protein-
KF946_RS10210 (KF946_10200)2125427..2125918-492WP_255801528.1hypothetical protein-
KF946_RS10215 (KF946_10205)2126114..2126377-264WP_011233548.1Txe/YoeB family addiction module toxinToxin
KF946_RS10220 (KF946_10210)2126370..2126624-255WP_011233547.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
KF946_RS10225 (KF946_10215)2126727..2127272-546WP_153849513.1AAA family ATPase-
KF946_RS10230 (KF946_10220)2127350..2127832-483WP_153849512.1GNAT family N-acetyltransferase-
KF946_RS10235 (KF946_10225)2127848..2128225-378WP_153849511.1hypothetical protein-
KF946_RS10240 (KF946_10230)2128235..2128651-417WP_153849510.1GFA family protein-
KF946_RS10245 (KF946_10235)2128755..2129474-720WP_153849509.1DUF4238 domain-containing protein-
KF946_RS10250 (KF946_10240)2129549..2130931-1383WP_153849508.1hypothetical protein-
KF946_RS10255 (KF946_10245)2131080..2131565-486WP_153849507.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10353.81 Da        Isoelectric Point: 9.7108

>T201332 WP_011233548.1 NZ_CP074073:c2126377-2126114 [Idiomarina loihiensis]
MSKRLLSWTDEAWKDYLYWQTQDKKTLKRINRLVADVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAADDSAITI
ISCRYHY

Download         Length: 264 bp

>T201332 NZ_CP098338:873672-874082 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9496.75 Da        Isoelectric Point: 5.6993

>AT201332 WP_011233547.1 NZ_CP074073:c2126624-2126370 [Idiomarina loihiensis]
MRIVSFTEARNGLKAVLDSVINDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNKSIAQYKEGKAKKRE
LLDE

Download         Length: 255 bp

>AT201332 NZ_CP098338:873425-873691 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ5R151

Antitoxin

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Source
ID
Structure
AlphaFold DBQ5QUM2

References