Detailed information of TA system TA201332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2126114..2126624
• Replicon: chromosome
• Accession: NZ_CP074073
• Organism: Idiomarina loihiensis strain SN11

Toxin (Protein)

• Gene name: relB
• Uniprot ID: Q5R151
• Locus tag: KF946_RS10215
• Protein ID: WP_011233548.1
• Coordinates: 2126114..2126377 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q5QUM2
• Locus tag: KF946_RS10220
• Protein ID: WP_011233547.1
• Coordinates: 2126370..2126624 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KF946_RS10185 (KF946_10175)	2121614..2122726	-	1113	WP_153849519.1	DUF4241 domain-containing protein	-
KF946_RS10190 (KF946_10180)	2122844..2123668	+	825	WP_153849518.1	hypothetical protein	-
KF946_RS10195 (KF946_10185)	2123752..2124306	-	555	WP_153849517.1	YaeQ family protein	-
KF946_RS10200 (KF946_10190)	2124347..2124727	-	381	WP_153849516.1	hypothetical protein	-
KF946_RS10205 (KF946_10195)	2124783..2125337	-	555	WP_153849515.1	hypothetical protein	-
KF946_RS10210 (KF946_10200)	2125427..2125918	-	492	WP_255801528.1	hypothetical protein	-
KF946_RS10215 (KF946_10205)	2126114..2126377	-	264	WP_011233548.1	Txe/YoeB family addiction module toxin	Toxin
KF946_RS10220 (KF946_10210)	2126370..2126624	-	255	WP_011233547.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KF946_RS10225 (KF946_10215)	2126727..2127272	-	546	WP_153849513.1	AAA family ATPase	-
KF946_RS10230 (KF946_10220)	2127350..2127832	-	483	WP_153849512.1	GNAT family N-acetyltransferase	-
KF946_RS10235 (KF946_10225)	2127848..2128225	-	378	WP_153849511.1	hypothetical protein	-
KF946_RS10240 (KF946_10230)	2128235..2128651	-	417	WP_153849510.1	GFA family protein	-
KF946_RS10245 (KF946_10235)	2128755..2129474	-	720	WP_153849509.1	DUF4238 domain-containing protein	-
KF946_RS10250 (KF946_10240)	2129549..2130931	-	1383	WP_153849508.1	hypothetical protein	-
KF946_RS10255 (KF946_10245)	2131080..2131565	-	486	WP_153849507.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10353.81 Da
• Isoelectric Point: 9.7108

>T201332 WP_011233548.1 NZ_CP074073:c2126377-2126114 [Idiomarina loihiensis]
MSKRLLSWTDEAWKDYLYWQTQDKKTLKRINRLVADVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAADDSAITI
ISCRYHY

Nucleotide

• Length: 264 bp

>T201332 NZ_CP098338:873672-874082 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9496.75 Da
• Isoelectric Point: 5.6993

>AT201332 WP_011233547.1 NZ_CP074073:c2126624-2126370 [Idiomarina loihiensis]
MRIVSFTEARNGLKAVLDSVINDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNKSIAQYKEGKAKKRE
LLDE

Nucleotide

• Length: 255 bp

>AT201332 NZ_CP098338:873425-873691 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: Q5R151

Antitoxin

• AlphaFold DB: Q5QUM2