Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4474881..4475716 | Replicon | chromosome |
| Accession | NZ_CP074052 | ||
| Organism | Escherichia coli strain PD23 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B1LDL9 |
| Locus tag | KFU85_RS21470 | Protein ID | WP_001094444.1 |
| Coordinates | 4474881..4475258 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7LDN9 |
| Locus tag | KFU85_RS21475 | Protein ID | WP_001285607.1 |
| Coordinates | 4475348..4475716 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU85_RS21440 (4471292) | 4471292..4472185 | + | 894 | WP_032172247.1 | WYL domain-containing protein | - |
| KFU85_RS21445 (4472383) | 4472383..4472583 | - | 201 | Protein_4203 | transposase | - |
| KFU85_RS21450 (4472703) | 4472703..4473484 | - | 782 | Protein_4204 | integrase arm-type DNA-binding domain-containing protein | - |
| KFU85_RS21455 (4473951) | 4473951..4474094 | - | 144 | Protein_4205 | hypothetical protein | - |
| KFU85_RS21460 (4474179) | 4474179..4474376 | - | 198 | WP_001327226.1 | DUF957 domain-containing protein | - |
| KFU85_RS21465 (4474396) | 4474396..4474884 | - | 489 | WP_000761685.1 | DUF5983 family protein | - |
| KFU85_RS21470 (4474881) | 4474881..4475258 | - | 378 | WP_001094444.1 | TA system toxin CbtA family protein | Toxin |
| KFU85_RS21475 (4475348) | 4475348..4475716 | - | 369 | WP_001285607.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KFU85_RS21480 (4475796) | 4475796..4476017 | - | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| KFU85_RS21485 (4476104) | 4476104..4476580 | - | 477 | WP_001384029.1 | RadC family protein | - |
| KFU85_RS21490 (4476595) | 4476595..4477080 | - | 486 | WP_000213722.1 | antirestriction protein | - |
| KFU85_RS21495 (4477172) | 4477172..4477990 | - | 819 | WP_001175175.1 | DUF932 domain-containing protein | - |
| KFU85_RS21500 (4478080) | 4478080..4478289 | - | 210 | WP_032150870.1 | DUF905 family protein | - |
| KFU85_RS21505 (4478319) | 4478319..4478996 | - | 678 | WP_001097301.1 | hypothetical protein | - |
| KFU85_RS21510 (4479144) | 4479144..4479824 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 4472479..4472583 | 104 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14087.02 Da Isoelectric Point: 7.3523
>T201329 WP_001094444.1 NZ_CP074052:c4475258-4474881 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T201329 NZ_CP098338:324617-324985 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13689.53 Da Isoelectric Point: 6.4669
>AT201329 WP_001285607.1 NZ_CP074052:c4475716-4475348 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT201329 NZ_CP098338:324399-324620 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | B1LDL9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0JLU8 |