Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3108935..3109779 Replicon chromosome
Accession NZ_CP074052
Organism Escherichia coli strain PD23

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag KFU85_RS15230 Protein ID WP_000854686.1
Coordinates 3108935..3109318 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag KFU85_RS15235 Protein ID WP_001285602.1
Coordinates 3109399..3109779 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU85_RS15190 (3103938) 3103938..3104429 - 492 WP_001300785.1 DUF1097 domain-containing protein -
KFU85_RS15195 (3104531) 3104531..3105085 - 555 WP_001001920.1 molecular chaperone YcdY -
KFU85_RS15200 (3105109) 3105109..3105846 - 738 WP_000283664.1 zinc-binding phosphatase -
KFU85_RS15205 (3105901) 3105901..3106839 - 939 WP_063814917.1 glyoxylate/hydroxypyruvate reductase GhrA -
KFU85_RS15215 (3107310) 3107310..3108151 - 842 Protein_2987 DUF4942 domain-containing protein -
KFU85_RS15220 (3108236) 3108236..3108433 - 198 WP_000839253.1 DUF957 domain-containing protein -
KFU85_RS15225 (3108450) 3108450..3108938 - 489 WP_032180032.1 DUF5983 family protein -
KFU85_RS15230 (3108935) 3108935..3109318 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
KFU85_RS15235 (3109399) 3109399..3109779 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU85_RS15240 (3109790) 3109790..3110473 - 684 WP_000086768.1 hypothetical protein -
KFU85_RS15245 (3110492) 3110492..3110713 - 222 WP_000692298.1 DUF987 domain-containing protein -
KFU85_RS15250 (3110776) 3110776..3111252 - 477 WP_001186726.1 RadC family protein -
KFU85_RS15255 (3111268) 3111268..3111753 - 486 WP_000214307.1 antirestriction protein -
KFU85_RS15260 (3111845) 3111845..3112666 - 822 WP_001761104.1 DUF932 domain-containing protein -
KFU85_RS15265 (3112767) 3112767..3112975 - 209 Protein_2997 DUF905 domain-containing protein -
KFU85_RS15270 (3113076) 3113076..3113531 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgB / csgD / csgE / csgF / csgG 3100318..3156286 55968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T201322 WP_000854686.1 NZ_CP074052:c3109318-3108935 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T201322 NZ_CP098335:4190199-4190417 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT201322 WP_001285602.1 NZ_CP074052:c3109779-3109399 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT201322 NZ_CP098335:4189798-4190172 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References