Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 4770..5292 Replicon plasmid pYLPD7c
Accession NZ_CP074050
Organism Escherichia coli strain PD7

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag KFU78_RS24550 Protein ID WP_000220560.1
Coordinates 5011..5292 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KFU78_RS24545 Protein ID WP_000121743.1
Coordinates 4770..5021 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU78_RS24520 (KFU78_24315) 441..722 + 282 WP_001185482.1 hypothetical protein -
KFU78_RS24525 (KFU78_24320) 747..1724 + 978 WP_024245156.1 hypothetical protein -
KFU78_RS24530 (KFU78_24325) 1721..2077 - 357 WP_000456533.1 DNA distortion polypeptide 3 -
KFU78_RS24535 (KFU78_24330) 2214..2660 - 447 Protein_4 hypothetical protein -
KFU78_RS24540 (KFU78_24335) 2700..3536 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
KFU78_RS24545 (KFU78_24340) 4770..5021 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KFU78_RS24550 (KFU78_24345) 5011..5292 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFU78_RS24555 (KFU78_24350) 5367..6064 + 698 WP_103215986.1 IS1-like element IS1A family transposase -
KFU78_RS24560 (KFU78_24355) 6111..6608 - 498 WP_162822358.1 hypothetical protein -
KFU78_RS24565 (KFU78_24360) 6693..7496 + 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
KFU78_RS24570 (KFU78_24365) 7496..8332 + 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
KFU78_RS24575 (KFU78_24370) 8458..8769 - 312 WP_001452736.1 hypothetical protein -
KFU78_RS24580 (KFU78_24375) 8805..9119 - 315 WP_000734776.1 TrbM/KikA/MpfK family conjugal transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3'')-Ib / aph(6)-Id - 1..19393 19393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T201306 WP_000220560.1 NZ_CP074050:5011-5292 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T201306 NZ_CP098330:881020-881427 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT201306 WP_000121743.1 NZ_CP074050:4770-5021 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT201306 NZ_CP098330:880773-881039 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References