Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4086986..4087581 Replicon chromosome
Accession NZ_CP074047
Organism Escherichia coli strain PD7

Toxin (Protein)


Gene name chpB Uniprot ID A0A827ISR3
Locus tag KFU78_RS19880 Protein ID WP_061359519.1
Coordinates 4086986..4087336 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A240D6C8
Locus tag KFU78_RS19885 Protein ID WP_001223212.1
Coordinates 4087330..4087581 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU78_RS19860 (4082435) 4082435..4083457 - 1023 WP_001301928.1 ABC transporter permease -
KFU78_RS19865 (4083471) 4083471..4084973 - 1503 WP_000205807.1 sugar ABC transporter ATP-binding protein -
KFU78_RS19870 (4085113) 4085113..4086069 - 957 WP_222898859.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KFU78_RS19875 (4086379) 4086379..4086909 + 531 WP_000055070.1 inorganic diphosphatase -
KFU78_RS19880 (4086986) 4086986..4087336 - 351 WP_061359519.1 endoribonuclease toxin ChpB Toxin
KFU78_RS19885 (4087330) 4087330..4087581 - 252 WP_001223212.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KFU78_RS19890 (4087793) 4087793..4088134 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KFU78_RS19895 (4088137) 4088137..4091916 - 3780 WP_061359518.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12506.43 Da        Isoelectric Point: 6.4786

>T201304 WP_061359519.1 NZ_CP074047:c4087336-4086986 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARQAKRIGLAADEVVEEALLRLQAVVK

Download         Length: 351 bp

>T201304 NZ_CP098330:284441-284716 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.6509

>AT201304 WP_001223212.1 NZ_CP074047:c4087581-4087330 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT201304 NZ_CP098330:284713-285072 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTAATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A827ISR3

Antitoxin

Source ID Structure
AlphaFold DB A0A240D6C8

References