Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1781948..1782780 Replicon chromosome
Accession NZ_CP074047
Organism Escherichia coli strain PD7

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag KFU78_RS08440 Protein ID WP_000854765.1
Coordinates 1781948..1782322 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A6L6I838
Locus tag KFU78_RS08445 Protein ID WP_032250192.1
Coordinates 1782412..1782780 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU78_RS08410 (1777846) 1777846..1778253 - 408 WP_077712527.1 transposase -
KFU78_RS08415 (1778361) 1778361..1778859 - 499 Protein_1643 transposase -
KFU78_RS08420 (1779053) 1779053..1780594 + 1542 WP_257187834.1 IS21-like element ISEc12 family transposase -
KFU78_RS08425 (1780609) 1780609..1781355 + 747 Protein_1645 IS21-like element ISEc12 family helper ATPase IstB -
KFU78_RS08430 (1781619) 1781619..1781699 - 81 Protein_1646 hypothetical protein -
KFU78_RS08435 (1781799) 1781799..1781951 - 153 Protein_1647 DUF5983 family protein -
KFU78_RS08440 (1781948) 1781948..1782322 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
KFU78_RS08445 (1782412) 1782412..1782780 - 369 WP_032250192.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU78_RS08450 (1782943) 1782943..1783164 - 222 WP_000692345.1 DUF987 domain-containing protein -
KFU78_RS08455 (1783227) 1783227..1783703 - 477 WP_001186774.1 RadC family protein -
KFU78_RS08460 (1783719) 1783719..1784192 - 474 WP_000855059.1 antirestriction protein -
KFU78_RS08465 (1784534) 1784534..1785352 - 819 WP_001234729.1 DUF932 domain-containing protein -
KFU78_RS08470 (1785470) 1785470..1785665 - 196 Protein_1654 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T201289 WP_000854765.1 NZ_CP074047:c1782322-1781948 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T201289 NZ_CP098322:c3189705-3189427 [Burkholderia gladioli]
ATGATCCAGTCATTCCGATGCAAGCGCACCGCCGCGCTGTTCGCCGGCGAATCGCCGCCGGCCTGGCGTGCCGTGGTACA
AGTGGCCCGGCGCAAGCTGGCCATGCTCGATGCGGCCCAGGCGCTGCGCGACCTGGCCGTGCCGCCCGGCAACCAACTCG
AAGGCCTGTTCGGCGATCGCGCGGGGCAATACAGCATCCGGATCAACGAGCGCTGGCGCCTTTGTTTCGTCTGGAGCAGC
CGGGGGCCCGAGCTCGTCGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13564.34 Da        Isoelectric Point: 6.3152

>AT201289 WP_032250192.1 NZ_CP074047:c1782780-1782412 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT201289 NZ_CP098322:c3189408-3189085 [Burkholderia gladioli]
ATGAATGCCAAGAGTGTGAAGCCCGTCAACGCGATGCCCGCCATCCACCCCGGCGAAATCCTGCGCGAGGAGTTCCTGGT
GCCGCTCGCGCTCAGCGTCAACGCGCTGTCGCTGGCGCTGATGGTGCCGGCCACCCGCATGCACGAGATCGTCAACGAGC
GGCGCGGCATCACCGCCGACACGGCCTACCGCCTGTCGCGCTACTTCGGCACCACGCCGGAGTTCTGGCTGGCCCTGCAG
GCCGACTACGACATCAAGACCCTGCCGAACCGCGACGAGATCGACCGCAAGGTCGATGCGCGCCCCAACGGCGCGGCGGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A6L6I838

References