Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4040822..4041476 Replicon chromosome
Accession NZ_CP074033
Organism Escherichia coli strain PI7

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag KFU70_RS19875 Protein ID WP_000244772.1
Coordinates 4041069..4041476 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KFU70_RS19870 Protein ID WP_000354046.1
Coordinates 4040822..4041088 (+) Length 89 a.a.

Genomic Context

KFU70_RS19845KFU70_RS19855KFU70_RS19860KFU70_RS19870KFU70_RS19875KFU70_RS19885KFU70_RS19890KFU70_RS19895KFU70_RS19850KFU70_RS19865KFU70_RS19880
Location: 4036110..4036853 (744 bp)
Type: Others
Protein ID: WP_000951948.1
Location: 4038388..4038699 (312 bp)
Type: Others
Protein ID: WP_001182954.1
Location: 4038863..4039522 (660 bp)
Type: Others
Protein ID: WP_257201011.1
Location: 4040822..4041088 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 4041069..4041476 (408 bp)
Type: Toxin
Protein ID: WP_000244772.1
Location: 4042149..4043045 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Location: 4043070..4043780 (711 bp)
Type: Others
Protein ID: WP_000715214.1
Location: 4043786..4045519 (1734 bp)
Type: Others
Protein ID: WP_000813215.1
Location: 4036910..4038343 (1434 bp)
Type: Others
Protein ID: WP_001363803.1
Location: 4039599..4040579 (981 bp)
Type: Others
Protein ID: WP_000886075.1
Location: 4041516..4042037 (522 bp)
Type: Others
Protein ID: WP_001055874.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KFU70_RS19845 (4036110)4036110..4036853+744WP_000951948.1SDR family oxidoreductase-
KFU70_RS19850 (4036910)4036910..4038343-1434WP_001363803.16-phospho-beta-glucosidase BglA-
KFU70_RS19855 (4038388)4038388..4038699+312WP_001182954.1N(4)-acetylcytidine aminohydrolase-
KFU70_RS19860 (4038863)4038863..4039522+660WP_257201011.1hemolysin III family protein-
KFU70_RS19865 (4039599)4039599..4040579-981WP_000886075.1tRNA-modifying protein YgfZ-
KFU70_RS19870 (4040822)4040822..4041088+267WP_000354046.1FAD assembly factor SdhEAntitoxin
KFU70_RS19875 (4041069)4041069..4041476+408WP_000244772.1protein YgfXToxin
KFU70_RS19880 (4041516)4041516..4042037-522WP_001055874.1flavodoxin FldB-
KFU70_RS19885 (4042149)4042149..4043045+897WP_000806638.1site-specific tyrosine recombinase XerD-
KFU70_RS19890 (4043070)4043070..4043780+711WP_000715214.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
KFU70_RS19895 (4043786)4043786..4045519+1734WP_000813215.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T201243 WP_000244772.1 NZ_CP074033:4041069-4041476 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T201243 NZ_CP098244:c304924-304652 [Oxalobacter formigenes]
ATGCTGGCATTGAAAACTACTGGCCAATTTCGCAAAGATCTGAAGCTGGCAAAAAAACGTGGATACAAGCTTGAGCTTCT
TGAAGAGGTACTGGAGATACTTCAAAATGAAGAAGCTCTTCCGGCAAAATTTAAGGACCACCCTTTAATCGGCCAATATG
CTGGCTTTCGTGAATGCCACATTCAGCCAGATTGGCTACTGATTTACATCGTCGATAACAATCAGCTTGTTCTGACGACT
GTACGCACAGGTACACATTCTGATTTGTTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT201243 WP_000354046.1 NZ_CP074033:4040822-4041088 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201243 NZ_CP098244:c305205-304924 [Oxalobacter formigenes]
ATGGCTAAAGACGCAAACATCAATATTCGTATTGAAAAAGAAGTGAAATCGAATGCTGAAGCATTATTTGCCAGCTTTGG
CATTACTGTTTCGGATGCGATCAAGATATTCCTTCACCAGTCTTTGATGACCGGTGGACTACCTTTTGAAGTACGGCAAC
CTCGTTATAATCGTGAGACTGAATTGGCAATGGATGAAGCAAGACAGATCATTGCAGGAAAGAAGAAATCAAAAAACTAT
CAATCAGCGTCAGACATGATTAACGATCTGGACAGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0XYB4

Antitoxin

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Source
ID
Structure
PDB6B58
PDB1X6I
PDB1X6J
PDB6C12
AlphaFold DBA0A7U9QD57

References