Detailed information of TA system TA020118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 757421..758025
• Replicon: chromosome
• Accession: NC_000907
• Organism: Haemophilus influenzae Rd KW20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HI_RS03785
• Protein ID: WP_005694595.1
• Coordinates: 757717..758025 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Y7JSS2
• Locus tag: HI_RS03780
• Protein ID: WP_005661259.1
• Coordinates: 757421..757717 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI_RS03765 (HI0708)	753952..755337	+	1386	WP_005694593.1	L-seryl-tRNA(Sec) selenium transferase	-
HI_RS03770 (HI0709)	755334..757193	+	1860	WP_005694594.1	selenocysteine-specific translation elongation factor	-
HI_RS03775	757177..757302	+	126	WP_005692348.1	hypothetical protein	-
HI_RS03780 (HI0710)	757421..757717	+	297	WP_005661259.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HI_RS03785 (HI0711)	757717..758025	+	309	WP_005694595.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HI_RS03790 (HI0712)	758082..761336	-	3255	WP_010869038.1	hemoglobin-haptoglobin-binding protein HgpC	-
HI_RS03795 (HI0713)	761637..762935	+	1299	WP_010869039.1	trigger factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11907.69 Da
• Isoelectric Point: 7.3189

>T20118 WP_005694595.1 NC_000907:757717-758025 [Haemophilus influenzae Rd KW20]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNIHSQTALK

Nucleotide

• Length: 309 bp

>T20118 NC_000907:757717-758025 [Haemophilus influenzae Rd KW20]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATATACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11015.37 Da
• Isoelectric Point: 4.4297

>AT20118 WP_005661259.1 NC_000907:757421-757717 [Haemophilus influenzae Rd KW20]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT20118 NC_000907:757421-757717 [Haemophilus influenzae Rd KW20]
ATGGCACTTACTAATTCCTCTATCAGTTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Y7JSS2