Detailed information of TA system TA020116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/-
• Location: 702730..703378
• Replicon: chromosome
• Accession: NC_000907
• Organism: Haemophilus influenzae Rd KW20

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0Y7JUP0
• Locus tag: HI_RS03525
• Protein ID: WP_005694481.1
• Coordinates: 703019..703378 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: HI_RS03520
• Protein ID: WP_005650837.1
• Coordinates: 702730..703026 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI_RS03495 (HI0654)	698164..698721	-	558	WP_005694489.1	DNA-3-methyladenine glycosylase I	-
HI_RS03500 (HI0655)	698718..699536	-	819	WP_005694487.1	shikimate dehydrogenase	-
HI_RS03505 (HI0656)	699540..700091	-	552	WP_005694486.1	Sua5/YciO/YrdC/YwlC family protein	-
HI_RS03510 (HI0656.1)	700107..700643	-	537	WP_005694485.1	type I DNA topoisomerase	-
HI_RS03515 (HI0658)	700653..702569	-	1917	WP_005694483.1	ABC transporter ATP-binding protein	-
HI_RS03520 (HI0659)	702730..703026	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
HI_RS03525 (HI0660)	703019..703378	-	360	WP_005694481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HI_RS03530 (HI0661)	703648..706644	-	2997	WP_164927859.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14321.67 Da
• Isoelectric Point: 10.1408

>T20116 WP_005694481.1 NC_000907:c703378-703019 [Haemophilus influenzae Rd KW20]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T20116 NC_000907:c703378-703019 [Haemophilus influenzae Rd KW20]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GATGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT20116 WP_005650837.1 NC_000907:c703026-702730 [Haemophilus influenzae Rd KW20]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT20116 NC_000907:c703026-702730 [Haemophilus influenzae Rd KW20]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTTCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0Y7JUP0