Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 49065..49587 Replicon plasmid pYLPM22c
Accession NZ_CP074022
Organism Escherichia coli strain PM22

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag KFU87_RS24450 Protein ID WP_000220560.1
Coordinates 49306..49587 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KFU87_RS24445 Protein ID WP_000121743.1
Coordinates 49065..49316 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU87_RS24420 (KFU87_24260) 44736..45017 + 282 WP_001185482.1 hypothetical protein -
KFU87_RS24425 (KFU87_24265) 45042..46019 + 978 WP_001269910.1 hypothetical protein -
KFU87_RS24430 (KFU87_24270) 46016..46372 - 357 WP_000456533.1 DNA distortion polypeptide 3 -
KFU87_RS24435 (KFU87_24275) 46509..46955 - 447 WP_001074386.1 hypothetical protein -
KFU87_RS24440 (KFU87_24280) 46995..47831 - 837 WP_024198970.1 replication initiation protein -
KFU87_RS24445 (KFU87_24285) 49065..49316 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KFU87_RS24450 (KFU87_24290) 49306..49587 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFU87_RS24455 (KFU87_24295) 49733..50056 + 324 WP_001181907.1 hypothetical protein -
KFU87_RS24460 (KFU87_24300) 50101..50346 + 246 WP_000356546.1 hypothetical protein -
KFU87_RS24465 (KFU87_24305) 50336..50551 + 216 WP_001180116.1 hypothetical protein -
KFU87_RS24470 (KFU87_24310) 50644..50973 + 330 WP_024216086.1 hypothetical protein -
KFU87_RS24475 (KFU87_24315) 51016..51195 + 180 WP_000439078.1 hypothetical protein -
KFU87_RS24480 (KFU87_24320) 51265..51414 + 150 WP_000003878.1 hypothetical protein -
KFU87_RS24485 (KFU87_24325) 51427..51699 + 273 WP_000160399.1 hypothetical protein -
KFU87_RS24490 (KFU87_24335) 52025..52570 + 546 WP_000757693.1 DNA distortion polypeptide 1 -
KFU87_RS24495 (KFU87_24340) 52573..53739 + 1167 WP_000539533.1 MobP1 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B - 1..54950 54950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T201138 WP_000220560.1 NZ_CP074022:49306-49587 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T201138 NZ_CP098223:c3856424-3856017 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCCCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTACGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT201138 WP_000121743.1 NZ_CP074022:49065-49316 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT201138 NZ_CP098223:c3856671-3856405 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References