Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 724259..724884 Replicon chromosome
Accession NC_000868
Organism Pyrococcus abyssi GE5

Toxin (Protein)


Gene name vapC Uniprot ID Q9V0L8
Locus tag PAB_RS04100 Protein ID WP_010867893.1
Coordinates 724474..724884 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q9V0L9
Locus tag PAB_RS04095 Protein ID WP_010867892.1
Coordinates 724259..724486 (+) Length 76 a.a.

Genomic Context

PAB_RS04070PAB_RS04075PAB_RS04095PAB_RS04100PAB_RS04105PAB_RS04110PAB_RS04115PAB_RS04065PAB_RS04080PAB_RS04085PAB_RS04090PAB_RS04120PAB_RS04125
Location: 720312..720728 (417 bp)
Type: Others
Protein ID: WP_010867887.1
Location: 720722..721531 (810 bp)
Type: Others
Protein ID: WP_084207595.1
Location: 724259..724486 (228 bp)
Type: Antitoxin
Protein ID: WP_010867892.1
Location: 724474..724884 (411 bp)
Type: Toxin
Protein ID: WP_010867893.1
Location: 725094..725417 (324 bp)
Type: Others
Protein ID: WP_010867894.1
Location: 725421..726110 (690 bp)
Type: Others
Protein ID: WP_010867895.1
Location: 726117..727046 (930 bp)
Type: Others
Protein ID: WP_048147263.1
Location: 719447..720190 (744 bp)
Type: Others
Protein ID: WP_010867886.1
Location: 721538..721954 (417 bp)
Type: Others
Protein ID: WP_010867889.1
Location: 722000..723367 (1368 bp)
Type: Others
Protein ID: WP_010867890.1
Location: 723417..724115 (699 bp)
Type: Others
Protein ID: WP_010867891.1
Location: 727043..727786 (744 bp)
Type: Others
Protein ID: WP_231845571.1
Location: 727930..729492 (1563 bp)
Type: Others
Protein ID: WP_048146661.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PAB_RS04065 (PAB1855)719447..720190-744WP_010867886.1Fe-S cluster assembly ATPase SufC-
PAB_RS04070 (PAB0517)720312..720728+417WP_010867887.1NifB/NifX family molybdenum-iron cluster-binding protein-
PAB_RS04075 (PAB0518)720722..721531+810WP_084207595.1MBL fold metallo-hydrolase-
PAB_RS04080 (PAB1854)721538..721954-417WP_010867889.1translation initiation factor IF-5A-
PAB_RS04085 (PAB1853)722000..723367-1368WP_010867890.1sodium-dependent transporter-
PAB_RS04090 (PAB1852)723417..724115-699WP_010867891.116S rRNA methyltransferase-
PAB_RS04095 (PAB3187)724259..724486+228WP_010867892.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
PAB_RS04100 (PAB0520)724474..724884+411WP_010867893.1PIN domain-containing proteinToxin
PAB_RS04105 (PAB0521)725094..725417+324WP_010867894.1hypothetical protein-
PAB_RS04110 (PAB0522)725421..726110+690WP_010867895.1ribose 5-phosphate isomerase A-
PAB_RS04115 (PAB0523)726117..727046+930WP_048147263.1RsmB/NOP family class I SAM-dependent RNA methyltransferase-
PAB_RS04120 (PAB1851)727043..727786-744WP_231845571.1alkaline-shock protein-
PAB_RS04125 (PAB1850)727930..729492-1563WP_048146661.1sodium-dependent transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(3-44)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16088.59 Da        Isoelectric Point: 5.5635

>T20112 WP_010867893.1 NC_000868:724474-724884 [Pyrococcus abyssi GE5]
MHAVIDTDILIYDTFEDLEFHEEARALLDSLSKWYVPTIVLQEYIWFFKRNNFSLLDAKSMLMEYVRDPRFKGLGESHEV
IIHALKILEENELSLSHFNDAIILYQAFSRKYPLATFDEKLRKLATKHGIRVLPEI

Download         Length: 411 bp

>T20112 NC_000868:724474-724884 [Pyrococcus abyssi GE5]
ATGCATGCAGTAATTGACACCGACATTCTTATCTACGACACCTTTGAGGATCTCGAGTTCCATGAAGAGGCTAGGGCTTT
GTTAGATTCACTTAGCAAGTGGTACGTGCCAACAATAGTTCTCCAGGAATACATCTGGTTCTTTAAAAGGAATAATTTCT
CTCTCCTCGATGCGAAATCAATGCTCATGGAGTACGTTAGGGATCCGAGGTTCAAGGGTTTAGGCGAAAGTCATGAAGTG
ATAATCCACGCTCTCAAGATTCTTGAGGAGAACGAACTTTCACTATCCCACTTTAATGATGCTATCATTCTTTACCAGGC
ATTCTCAAGAAAATACCCACTCGCAACGTTCGACGAAAAACTAAGAAAACTAGCAACAAAACATGGGATCAGAGTGTTGC
CTGAAATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8868.42 Da        Isoelectric Point: 9.9364

>AT20112 WP_010867892.1 NC_000868:724259-724486 [Pyrococcus abyssi GE5]
MPITKVTRNYQVTLPAEVRKVLGIREGDFLEVEVRGDEIVMRKLRKNRRTLKLGRNLTPEDIERIIEEGMRECMQ

Download         Length: 228 bp

>AT20112 NC_000868:724259-724486 [Pyrococcus abyssi GE5]
ATGCCCATAACGAAAGTGACTAGGAACTATCAAGTGACCCTTCCAGCAGAGGTCAGAAAAGTGCTTGGAATTAGGGAGGG
TGATTTTCTTGAGGTTGAAGTGAGGGGTGATGAAATCGTTATGAGGAAGTTGAGGAAAAACAGGAGAACACTGAAACTTG
GAAGGAATTTAACCCCCGAAGATATCGAAAGGATTATAGAGGAGGGTATGCGGGAATGCATGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9V0L8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9V0L9

References