Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 430110..430705 Replicon chromosome
Accession NZ_CP074019
Organism Escherichia coli strain PM22

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KFU87_RS02050 Protein ID WP_000239579.1
Coordinates 430355..430705 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KFU87_RS02045 Protein ID WP_001223208.1
Coordinates 430110..430361 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU87_RS02035 (425774) 425774..429553 + 3780 WP_000060917.1 autotransporter assembly complex protein TamB -
KFU87_RS02040 (429556) 429556..429897 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KFU87_RS02045 (430110) 430110..430361 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KFU87_RS02050 (430355) 430355..430705 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KFU87_RS02055 (430785) 430785..431315 - 531 WP_000055072.1 inorganic diphosphatase -
KFU87_RS02060 (431625) 431625..432581 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KFU87_RS02065 (432891) 432891..434393 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
KFU87_RS02070 (434407) 434407..435429 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T201103 WP_000239579.1 NZ_CP074019:430355-430705 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T201103 NZ_CP098219:519330-519503 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT201103 WP_001223208.1 NZ_CP074019:430110-430361 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT201103 NZ_CP098219:518994-519302 [Escherichia coli]
ATAGGGGCAAATCCAGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGT
GTTCTTAAGGTTAAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAAT
TGAATGAAAACTCCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGAC
TTACCGGATATTGATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References