Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 78649..79196 Replicon plasmid pYLPI24a
Accession NZ_CP074013
Organism Escherichia coli strain PI24

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KFU81_RS23115 Protein ID WP_244578848.1
Coordinates 78918..79196 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A829FT18
Locus tag KFU81_RS23110 Protein ID WP_000079938.1
Coordinates 78649..78918 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU81_RS23080 (KFU81_22935) 74487..74744 - 258 Protein_73 Tn3 family transposase -
KFU81_RS23090 (KFU81_22945) 76004..76363 + 360 WP_170877903.1 hypothetical protein -
KFU81_RS23095 (KFU81_22950) 76411..77388 - 978 WP_000600827.1 tyrosine-type recombinase/integrase -
KFU81_RS23100 (KFU81_22955) 77580..77937 + 358 Protein_77 IS1 family transposase -
KFU81_RS23105 (KFU81_22960) 78436..78576 + 141 WP_160784086.1 hypothetical protein -
KFU81_RS23110 (KFU81_22965) 78649..78918 + 270 WP_000079938.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
KFU81_RS23115 (KFU81_22970) 78918..79196 + 279 WP_244578848.1 type II toxin-antitoxin system toxin YacB Toxin
KFU81_RS23120 (KFU81_22975) 79249..79386 + 138 WP_152931508.1 hypothetical protein -
KFU81_RS23125 79463..79599 + 137 Protein_82 IS5/IS1182 family transposase -
KFU81_RS23130 (KFU81_22980) 79724..80017 - 294 WP_223429961.1 biofilm development regulator YmgB/AriR family protein -
KFU81_RS23135 (KFU81_22985) 80358..82157 - 1800 Protein_84 Tn3 family transposase -
KFU81_RS23140 (KFU81_22990) 82252..83682 + 1431 Protein_85 IS4-like element IS50R family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(M) / dfrA16 / blaCARB-2 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / mef(B) / floR / tet(D) / aph(3')-IIa / aph(3'')-Ib / aph(6)-Id / tet(B) - 1..140432 140432
- inside IScluster/Tn tet(M) / dfrA16 / blaCARB-2 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / mef(B) / floR / tet(D) / aph(3')-IIa - 29748..84505 54757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10729.39 Da        Isoelectric Point: 8.4615

>T201100 WP_244578848.1 NZ_CP074013:78918-79196 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMVAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSPWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T201100 NZ_CP098217:c4836626-4836519 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10251.64 Da        Isoelectric Point: 10.1734

>AT201100 WP_000079938.1 NZ_CP074013:78649-78918 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKRGDVLPHDMVESSAAAWRD
EMSRKVADK

Download         Length: 270 bp

>AT201100 NZ_CP098217:4836684-4836738 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829FT18

References