Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3984424..3985222 | Replicon | chromosome |
| Accession | NZ_CP074012 | ||
| Organism | Escherichia coli strain PI24 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1X1M0U2 |
| Locus tag | KFU81_RS19515 | Protein ID | WP_000854919.1 |
| Coordinates | 3984424..3984801 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2G4AEZ5 |
| Locus tag | KFU81_RS19520 | Protein ID | WP_001285608.1 |
| Coordinates | 3984848..3985222 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU81_RS19480 (3979645) | 3979645..3980751 | + | 1107 | WP_001315214.1 | N-acetylneuraminate epimerase | - |
| KFU81_RS19485 (3980816) | 3980816..3981796 | + | 981 | WP_001295601.1 | sialate O-acetylesterase | - |
| KFU81_RS19490 (3981804) | 3981804..3982454 | - | 651 | Protein_3812 | HNH endonuclease | - |
| KFU81_RS19495 (3982591) | 3982591..3982734 | + | 144 | Protein_3813 | HNH endonuclease | - |
| KFU81_RS19500 (3983494) | 3983494..3983637 | - | 144 | Protein_3814 | hypothetical protein | - |
| KFU81_RS19505 (3983722) | 3983722..3983919 | - | 198 | WP_001403937.1 | DUF957 domain-containing protein | - |
| KFU81_RS19510 (3983939) | 3983939..3984427 | - | 489 | WP_000777665.1 | DUF5983 family protein | - |
| KFU81_RS19515 (3984424) | 3984424..3984801 | - | 378 | WP_000854919.1 | TA system toxin CbtA family protein | Toxin |
| KFU81_RS19520 (3984848) | 3984848..3985222 | - | 375 | WP_001285608.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KFU81_RS19525 (3985302) | 3985302..3985523 | - | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| KFU81_RS19530 (3985610) | 3985610..3986086 | - | 477 | WP_001186188.1 | RadC family protein | - |
| KFU81_RS19535 (3986101) | 3986101..3986328 | - | 228 | Protein_3821 | antirestriction protein | - |
| KFU81_RS19540 (3986402) | 3986402..3987579 | + | 1178 | WP_085968792.1 | IS3 family transposase | - |
| KFU81_RS19550 (3988775) | 3988775..3988837 | + | 63 | WP_113705808.1 | hypothetical protein | - |
| KFU81_RS19555 (3988848) | 3988848..3989545 | - | 698 | Protein_3825 | IS1 family transposase | - |
| KFU81_RS19560 (3989632) | 3989632..3989700 | - | 69 | WP_211180522.1 | protein YkiE | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fimE / fimB | 3975003..4001316 | 26313 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14037.97 Da Isoelectric Point: 7.9086
>T201097 WP_000854919.1 NZ_CP074012:c3984801-3984424 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ
Download Length: 378 bp
>T201097 NZ_CP098217:4423726-4424190 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13610.37 Da Isoelectric Point: 5.5051
>AT201097 WP_001285608.1 NZ_CP074012:c3985222-3984848 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS
Download Length: 375 bp
>AT201097 NZ_CP098217:4423391-4423726 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1M0U2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G4AEZ5 |