20105

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/-
Location 4823065..4824689 Replicon chromosome
Accession LT629788
Organism Pseudomonas moraviensis strain BS3668

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag SAMN04490196_4538 Protein ID SDU70079.1
Coordinates 4823340..4824689 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SAMN04490196_4537 Protein ID SDU70070.1
Coordinates 4823065..4823343 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMN04490196_4531 4818421..4819119 + 699 SDU70015.1 negative transcriptional regulator, PaiB family -
SAMN04490196_4532 4819130..4819576 + 447 SDU70024.1 Ribosomal protein S18 acetylase RimI -
SAMN04490196_4533 4819589..4820260 + 672 SDU70034.1 Protein N-acetyltransferase, RimJ/RimL family -
SAMN04490196_4534 4820382..4821284 - 903 SDU70041.1 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) -
SAMN04490196_4535 4821398..4822216 + 819 SDU70050.1 amino acid ABC transporter substrate-binding protein, PAAT family -
SAMN04490196_4536 4822213..4823049 + 837 SDU70061.1 amino acid ABC transporter membrane protein, PAAT family -
SAMN04490196_4537 4823065..4823343 - 279 SDU70070.1 Helix-turn-helix Antitoxin
SAMN04490196_4538 4823340..4824689 - 1350 SDU70079.1 serine/threonine-protein kinase HipA Toxin
SAMN04490196_4539 4825059..4827254 + 2196 SDU70090.1 outer membrane autotransporter barrel domain-containing protein -
SAMN04490196_4541 4827449..4829257 - 1809 SDU70100.1 pyruvate carboxylase subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49808.28 Da        Isoelectric Point: 4.9302

>T20105 SDU70079.1 LT629788:c4824689-4823340 [Pseudomonas moraviensis]
MYNLTLQIFTAGQWHDAMTLDFDDPEKGFESRCSFGYEADYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMRRFDRQVEDGAVSRFAVESIYSLAEVTTPGSAMNHLDVIRMLAGLWRKAGQASQIPGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPKELERAGDVDWRGVCRVLADSADPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

>T20105 LT629788:c4824689-4823340 [Pseudomonas moraviensis]
ATGTATAACCTGACACTCCAGATCTTCACCGCCGGGCAATGGCACGACGCGATGACTCTTGACTTCGATGATCCGGAAAA
AGGCTTTGAAAGCCGCTGCAGTTTTGGCTATGAAGCGGACTATCTGGTGGAAAACATTGAGTTGATCGGGTCGCCTTTTT
CCCAAGCCGTGAGTGCCCTGTATCCGCTGGATTGGGAAGGTCGGCGCGCGAAGACACCAGCCTTTGTCCACGACATCGCA
CCGGCAGGCGCAGCCAAGCGGTTTCTCCTCGCCCGCCTGGGTCAGGAAAGACCCGCCGAGATCAGCGCCGATCTGTTTCT
GCTGGGTCGCAGTACACCGGCTCCCATTGGCAACATGCGAATAAAGGAATCGGCGGAAGCAGTCGATGAGAGGAAGCCGA
TCGGATTCAAGCGCGAAGAGGTCATTAGCCGCGACAACCGCTTTCTTGAATATGCCTACGAGCTGGGCGCGGCCATCGGT
GGCGCGACGGGGGCAGGTGGTGAAGCTCCGAAGCTATTACTGGCAGAGAACAGCGCCGGGCTTCTGTATCCCGACGCGGT
ATTGGACGATGAAGAAGTGCGACAGCACTGGTTCGTGAAATTCGCCAGAAACAGGGGCGGGCAGACCGATCAGGACATCC
TGCGCAGCGAATTCCATTACTACAAAGCGCTGCAGACATTGGGCATCGAAACGGTCGCGGCAGAAGGCCTGGCCTTGGAA
GAGGCGAACAAACCGAGTTTGTGGATGCGGCGTTTTGATCGACAAGTGGAAGATGGGGCGGTGTCGCGTTTTGCCGTCGA
ATCGATTTATTCGCTGGCTGAAGTGACGACGCCTGGCAGCGCCATGAATCATCTGGACGTGATCCGCATGCTCGCCGGGC
TATGGCGCAAAGCGGGTCAGGCCAGCCAGATTCCCGGCCTCGTCGCCGATTACCTGCGTCGCGACCTGATCAATAAAATC
CTCGGAAACTCCGATAACCACGGTCGTAACACGGCGATCATCCGGCAAGAGAACGCTTTCCAACTCGCGCCTATTTATGA
CCTCGCCCCGATGGTCATGGATGACGAAGGCGTGACGCGTACGACCAAATGGCCAAAAGAGTTGGAGCGGGCGGGCGATG
TCGATTGGCGAGGTGTCTGCCGCGTATTGGCCGATAGCGCAGATCCGCACGATTCGTTGGCGGGGCTGGATGCCTCTGCG
CTGTTCGAAGGCCTGCGCGCGGATGCCCGCCGTCTGGCCGCACTGCCGGATATTCTTGCGGCCAGCGGTTTGCCCGCCAG
AACCATGAATCACCCGAGCGTTCATCTGAAAAACCTCGAGCAACGTTTGAAAGAGTGGGACCTGCAATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10318.09 Da        Isoelectric Point: 10.7364

>AT20105 SDU70070.1 LT629788:c4823343-4823065 [Pseudomonas moraviensis]
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTV

Download         Length: 279 bp

>AT20105 LT629788:c4823343-4823065 [Pseudomonas moraviensis]
ATGAGTCTGACCGTCCTCGAGCGCACGGCGCTCATCGAAAGCATTCAGCAATCACTGGCCGAAGGCACTCTGGAAATCGG
TGACGCCGTGCGCCGTTTACGGGTCGAAGTCACCGGTCTGCATCAGACCCAGTTTGCGAAGATGTGCAAGATTTCAGTGC
GCACGCTGGTGCATATCGAACATGGCGAAGGCAACCAGACATTGAAGTCGCTGAACGCGGTGTTCCGCCCATTCGGCATG
AAAATGGGTGTTGTGCGAATACGCCGGGACACCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References