Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 89975..90522 Replicon plasmid pYLPM4a
Accession NZ_CP074002
Organism Escherichia coli strain PM4

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KFU80_RS23085 Protein ID WP_244578848.1
Coordinates 89975..90253 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A829FT18
Locus tag KFU80_RS23090 Protein ID WP_000079938.1
Coordinates 90253..90522 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU80_RS23060 (KFU80_22865) 85489..86919 - 1431 Protein_87 IS4-like element IS50R family transposase -
KFU80_RS23065 (KFU80_22870) 87014..88813 + 1800 Protein_88 Tn3 family transposase -
KFU80_RS23070 (KFU80_22875) 89154..89447 + 294 WP_223429961.1 biofilm development regulator YmgB/AriR family protein -
KFU80_RS23075 89572..89708 - 137 Protein_90 IS5/IS1182 family transposase -
KFU80_RS23080 89785..89919 - 135 WP_257187774.1 hypothetical protein -
KFU80_RS23085 (KFU80_22880) 89975..90253 - 279 WP_244578848.1 type II toxin-antitoxin system toxin YacB Toxin
KFU80_RS23090 (KFU80_22885) 90253..90522 - 270 WP_000079938.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
KFU80_RS23095 (KFU80_22890) 90595..90735 - 141 WP_160784086.1 hypothetical protein -
KFU80_RS23100 (KFU80_22895) 91234..91591 - 358 Protein_95 IS1 family transposase -
KFU80_RS23105 (KFU80_22900) 91783..92760 + 978 WP_000600827.1 tyrosine-type recombinase/integrase -
KFU80_RS23110 (KFU80_22905) 92808..93167 - 360 WP_170877903.1 hypothetical protein -
KFU80_RS23115 (KFU80_22910) 93189..94309 + 1121 WP_085950818.1 IS3-like element ISSen4 family transposase -
KFU80_RS23120 (KFU80_22915) 94427..94684 + 258 Protein_99 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(M) / dfrA16 / blaCARB-2 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / mef(B) / tet(B) / aph(6)-Id / aph(3'')-Ib / aph(3')-IIa - 1..136494 136494
- inside IScluster/Tn aph(3')-IIa - 84666..103461 18795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10729.39 Da        Isoelectric Point: 8.4615

>T201028 WP_244578848.1 NZ_CP074002:c90253-89975 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMVAIELDERIGYSASSLAGQPYKGRNGRVEGARELVIHPHFVLVYEVDSPWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T201028 NZ_CP098210:c4791184-4791077 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10251.64 Da        Isoelectric Point: 10.1734

>AT201028 WP_000079938.1 NZ_CP074002:c90522-90253 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLKRGDVLPHDMVESSAAAWRD
EMSRKVADK

Download         Length: 270 bp

>AT201028 NZ_CP098210:4791242-4791296 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829FT18

References