Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3994227..3995062 Replicon chromosome
Accession NZ_CP074001
Organism Escherichia coli strain PM4

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KFU80_RS19505 Protein ID WP_126697185.1
Coordinates 3994227..3994604 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KFU80_RS19510 Protein ID WP_021542768.1
Coordinates 3994694..3995062 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU80_RS19470 (3989442) 3989442..3990548 + 1107 WP_001353974.1 N-acetylneuraminate epimerase -
KFU80_RS19475 (3990613) 3990613..3991593 + 981 WP_001295601.1 sialate O-acetylesterase -
KFU80_RS19480 (3991601) 3991601..3992251 - 651 WP_001037966.1 HNH endonuclease -
KFU80_RS19485 (3992388) 3992388..3992531 + 144 Protein_3810 HNH endonuclease -
KFU80_RS19490 (3993299) 3993299..3993448 - 150 Protein_3811 restriction endonuclease subunit M -
KFU80_RS19495 (3993533) 3993533..3993730 - 198 WP_000839281.1 DUF957 domain-containing protein -
KFU80_RS19500 (3993742) 3993742..3994230 - 489 WP_196010886.1 DUF5983 family protein -
KFU80_RS19505 (3994227) 3994227..3994604 - 378 WP_126697185.1 TA system toxin CbtA family protein Toxin
KFU80_RS19510 (3994694) 3994694..3995062 - 369 WP_021542768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU80_RS19515 (3995225) 3995225..3995446 - 222 WP_000692345.1 DUF987 domain-containing protein -
KFU80_RS19520 (3995509) 3995509..3995985 - 477 WP_001186746.1 RadC family protein -
KFU80_RS19525 (3996001) 3996001..3996486 - 486 WP_000849588.1 antirestriction protein -
KFU80_RS19530 (3996541) 3996541..3997359 - 819 WP_001234620.1 DUF932 domain-containing protein -
KFU80_RS19535 (3997459) 3997459..3997692 - 234 WP_001119729.1 DUF905 family protein -
KFU80_RS19540 (3997771) 3997771..3998226 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14063.98 Da        Isoelectric Point: 7.2919

>T201026 WP_126697185.1 NZ_CP074001:c3994604-3994227 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T201026 NZ_CP098210:c4790217-4790110 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13573.33 Da        Isoelectric Point: 6.4789

>AT201026 WP_021542768.1 NZ_CP074001:c3995062-3994694 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWRLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT201026 NZ_CP098210:4790265-4790331 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References