Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 96861..97558 Replicon chromosome
Accession LT629788
Organism Pseudomonas moraviensis strain BS3668

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SAMN04490196_0103 Protein ID SDU01971.1
Coordinates 97376..97558 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SAMN04490196_0102 Protein ID SDU01951.1
Coordinates 96861..97325 (-) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMN04490196_0094 92112..92894 + 783 SDU01749.1 hypothetical protein -
SAMN04490196_0095 92884..93690 + 807 SDU01775.1 phage DNA replication protein (predicted replicative helicase loader) -
SAMN04490196_0096 93692..94264 + 573 SDU01795.1 hypothetical protein -
SAMN04490196_0097 94261..94668 + 408 SDU01816.1 NinB protein -
SAMN04490196_0098 94658..94981 + 324 SDU01846.1 hypothetical protein -
SAMN04490196_0099 94972..95583 + 612 SDU01877.1 Bacteriophage Lambda NinG protein -
SAMN04490196_0100 95580..96161 + 582 SDU01906.1 hypothetical protein -
SAMN04490196_0101 96329..96598 + 270 SDU01926.1 hypothetical protein -
SAMN04490196_0102 96861..97325 - 465 SDU01951.1 antitoxin HicB Antitoxin
SAMN04490196_0103 97376..97558 - 183 SDU01971.1 mRNA interferase HicA Toxin
SAMN04490196_0104 97728..98051 + 324 SDU01993.1 phage holin, lambda family -
SAMN04490196_0105 98048..98434 + 387 SDU02018.1 phage lysis regulatory protein, LysB family -
SAMN04490196_0106 98693..98914 + 222 SDU02041.1 Uncharacterized conserved protein YodC, DUF2158 family -
SAMN04490196_0107 99063..99710 + 648 SDU02062.1 phage terminase small subunit -
SAMN04490196_0108 99685..100965 + 1281 SDU02088.1 Terminase-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 76818..125712 48894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-61)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7084.22 Da        Isoelectric Point: 10.9186

>T20099 SDU01971.1 LT629788:c97558-97376 [Pseudomonas moraviensis]
MKYSEFRRWLEARGVEFSKSAKGSHFKIRYKDRQTIFPSHGSKEIGEGLRKEIIKQLGLK

Download         Length: 183 bp

>T20099 LT629788:c97558-97376 [Pseudomonas moraviensis]
ATGAAGTACAGCGAGTTCAGAAGATGGTTGGAGGCCCGAGGGGTCGAGTTTTCGAAGTCAGCAAAAGGCAGCCACTTCAA
GATTCGCTACAAGGACCGGCAAACGATCTTTCCAAGCCACGGATCGAAGGAAATAGGTGAAGGGCTTCGGAAAGAGATAA
TCAAACAACTGGGCCTCAAATGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16815.05 Da        Isoelectric Point: 6.0052

>AT20099 SDU01951.1 LT629788:c97325-96861 [Pseudomonas moraviensis]
MYNYKIVAHEESDHFWSTCPDIPEAHSAGDTLEELLENAADGLTLALSIYVDQKREIPHASGQGDHHVRLSAVTLAKIIL
WNQLIHTGKSKADLAAMLGISPTAAARLVDFEHTSKMESLEDALDQFGLRLQIVKEHAFAAGTGRPPKGLAPRP

Download         Length: 465 bp

>AT20099 LT629788:c97325-96861 [Pseudomonas moraviensis]
ATGTACAACTACAAAATCGTCGCTCACGAAGAGTCCGATCATTTCTGGTCGACATGCCCAGACATCCCAGAAGCTCATAG
CGCTGGGGATACGCTGGAGGAGCTGCTGGAAAATGCTGCCGATGGGCTTACCTTGGCGCTCTCGATTTACGTGGATCAAA
AACGTGAAATTCCTCACGCGTCCGGACAGGGCGATCACCACGTGCGGCTTTCGGCCGTCACGCTGGCAAAAATCATCCTC
TGGAATCAATTGATCCACACCGGAAAATCAAAAGCAGACCTGGCTGCGATGCTGGGTATCTCTCCTACAGCAGCCGCTCG
GCTTGTTGATTTCGAGCACACGTCGAAGATGGAAAGCTTGGAGGACGCTCTCGATCAGTTCGGCCTTCGACTGCAGATCG
TGAAGGAGCATGCATTTGCCGCTGGCACCGGGCGACCTCCAAAAGGTTTGGCTCCGAGGCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References