Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1853388..1854220 Replicon chromosome
Accession NZ_CP073994
Organism Escherichia coli strain MB1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag KFU72_RS08855 Protein ID WP_001514886.1
Coordinates 1853388..1853762 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag KFU72_RS08860 Protein ID WP_001360327.1
Coordinates 1853852..1854220 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU72_RS08820 (1848904) 1848904..1849377 + 474 WP_001105385.1 DNA gyrase inhibitor SbmC -
KFU72_RS08825 (1849576) 1849576..1850634 + 1059 WP_032181141.1 FUSC family protein -
KFU72_RS08830 (1850806) 1850806..1851135 + 330 WP_000450409.1 DUF496 family protein -
KFU72_RS08835 (1851236) 1851236..1851502 - 267 WP_063121129.1 EutP/PduV family microcompartment system protein -
KFU72_RS08840 (1851872) 1851872..1852243 - 372 WP_001295631.1 IS110 family transposase -
KFU72_RS08845 (1853059) 1853059..1853139 - 81 Protein_1730 hypothetical protein -
KFU72_RS08850 (1853239) 1853239..1853391 - 153 Protein_1731 DUF5983 family protein -
KFU72_RS08855 (1853388) 1853388..1853762 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
KFU72_RS08860 (1853852) 1853852..1854220 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU72_RS08865 (1854383) 1854383..1854604 - 222 WP_000692286.1 DUF987 domain-containing protein -
KFU72_RS08870 (1854667) 1854667..1855143 - 477 WP_001186774.1 RadC family protein -
KFU72_RS08875 (1855159) 1855159..1855431 - 273 Protein_1736 antirestriction protein -
KFU72_RS08880 (1855427) 1855427..1857640 - 2214 Protein_1737 Ag43/Cah family autotransporter adhesin -
KFU72_RS08885 (1858013) 1858013..1858885 - 873 WP_193107544.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T200966 WP_001514886.1 NZ_CP073994:c1853762-1853388 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T200966 NZ_CP098203:684718-685032 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT200966 WP_001360327.1 NZ_CP073994:c1854220-1853852 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT200966 NZ_CP098203:685029-685445 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References