Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3890267..3890793 Replicon chromosome
Accession NZ_CP073981
Organism Escherichia coli strain MB19

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KFU84_RS18645 Protein ID WP_000323025.1
Coordinates 3890506..3890793 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KFU84_RS18640 Protein ID WP_000534858.1
Coordinates 3890267..3890506 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU84_RS18605 (3885298) 3885298..3885606 + 309 Protein_3609 DUF977 family protein -
KFU84_RS18610 (3885603) 3885603..3886092 + 490 Protein_3610 class I SAM-dependent methyltransferase -
KFU84_RS18615 (3886570) 3886570..3886990 + 421 Protein_3611 hypothetical protein -
KFU84_RS18620 (3887646) 3887646..3888695 + 1050 Protein_3612 ISNCY family transposase -
KFU84_RS18625 (3888816) 3888816..3888965 + 150 WP_011443592.1 protein YdfW -
KFU84_RS18630 (3889402) 3889402..3889734 - 333 WP_001301033.1 FlxA-like family protein -
KFU84_RS18635 (3889937) 3889937..3890242 - 306 WP_071593935.1 protein YdfV -
KFU84_RS18640 (3890267) 3890267..3890506 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KFU84_RS18645 (3890506) 3890506..3890793 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KFU84_RS18650 (3890865) 3890865..3891020 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KFU84_RS18655 (3891309) 3891309..3891986 + 678 WP_001339397.1 IS66-like element accessory protein TnpA -
KFU84_RS18660 (3891986) 3891986..3892333 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
KFU84_RS18665 (3892353) 3892353..3893924 + 1572 WP_179784855.1 IS66-like element ISCro1 family transposase -
KFU84_RS18670 (3893962) 3893962..3894195 + 234 WP_257182220.1 hypothetical protein -
KFU84_RS18675 (3894262) 3894262..3894540 + 279 WP_001515373.1 hypothetical protein -
KFU84_RS18680 (3894542) 3894542..3895591 + 1050 WP_032182205.1 DUF968 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3868946..3910087 41141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T200903 WP_000323025.1 NZ_CP073981:3890506-3890793 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T200903 NZ_CP098195:3825414-3825956 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT200903 WP_000534858.1 NZ_CP073981:3890267-3890506 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT200903 NZ_CP098195:3825119-3825430 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References