Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4062024..4062859 Replicon chromosome
Accession NZ_CP073974
Organism Escherichia coli strain MB22

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag KFU73_RS19705 Protein ID WP_000854821.1
Coordinates 4062024..4062401 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A4Q1HU91
Locus tag KFU73_RS19710 Protein ID WP_053287563.1
Coordinates 4062491..4062859 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU73_RS19680 (4057689) 4057689..4059941 - 2253 Protein_3829 alpha-amylase family glycosyl hydrolase -
KFU73_RS19690 (4060675) 4060675..4061520 - 846 WP_063101552.1 DUF4942 domain-containing protein -
KFU73_RS19695 (4061605) 4061605..4061802 - 198 WP_088209831.1 DUF957 domain-containing protein -
KFU73_RS19700 (4061830) 4061830..4062027 - 198 Protein_3832 DUF5983 family protein -
KFU73_RS19705 (4062024) 4062024..4062401 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KFU73_RS19710 (4062491) 4062491..4062859 - 369 WP_053287563.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU73_RS19715 (4062939) 4062939..4063160 - 222 WP_000692309.1 DUF987 domain-containing protein -
KFU73_RS19720 (4063229) 4063229..4063705 - 477 WP_001186747.1 RadC family protein -
KFU73_RS19725 (4063720) 4063720..4064205 - 486 WP_000214317.1 antirestriction protein -
KFU73_RS19730 (4064296) 4064296..4065114 - 819 WP_053292454.1 DUF932 domain-containing protein -
KFU73_RS19735 (4065441) 4065441..4065851 - 411 Protein_3839 autotransporter adhesin family protein -
KFU73_RS19740 (4066020) 4066020..4066892 - 873 WP_053292456.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T200882 WP_000854821.1 NZ_CP073974:c4062401-4062024 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T200882 NZ_CP098193:c60684-60535 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13663.36 Da        Isoelectric Point: 6.4768

>AT200882 WP_053287563.1 NZ_CP073974:c4062859-4062491 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNSRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT200882 NZ_CP098193:60728-60789 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q1HU91

References