Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 733909..734547 Replicon chromosome
Accession NZ_CP073974
Organism Escherichia coli strain MB22

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KFU73_RS03750 Protein ID WP_000813794.1
Coordinates 734371..734547 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KFU73_RS03745 Protein ID WP_001270286.1
Coordinates 733909..734325 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU73_RS03725 (729061) 729061..730002 - 942 WP_001251319.1 ABC transporter permease -
KFU73_RS03730 (730003) 730003..731016 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
KFU73_RS03735 (731034) 731034..732179 - 1146 WP_000047429.1 ABC transporter substrate-binding protein -
KFU73_RS03740 (732421) 732421..733830 - 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
KFU73_RS03745 (733909) 733909..734325 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KFU73_RS03750 (734371) 734371..734547 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KFU73_RS03755 (734769) 734769..734999 + 231 WP_000494244.1 YncJ family protein -
KFU73_RS03760 (735091) 735091..737052 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KFU73_RS03765 (737125) 737125..737661 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KFU73_RS03770 (737753) 737753..738928 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T200874 WP_000813794.1 NZ_CP073974:c734547-734371 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T200874 NZ_CP098192:2189686-2189789 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT200874 WP_001270286.1 NZ_CP073974:c734325-733909 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT200874 NZ_CP098192:c2189827-2189556 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References