Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1905541..1906376 Replicon chromosome
Accession NZ_CP073962
Organism Escherichia coli strain MB31

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KFU79_RS09075 Protein ID WP_042046912.1
Coordinates 1905541..1905918 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KFU79_RS09080 Protein ID WP_073961352.1
Coordinates 1906008..1906376 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU79_RS09040 (1901061) 1901061..1901534 + 474 WP_001105407.1 DNA gyrase inhibitor SbmC -
KFU79_RS09045 (1901732) 1901732..1902790 + 1059 WP_001200895.1 FUSC family protein -
KFU79_RS09050 (1902962) 1902962..1903291 + 330 WP_000450409.1 DUF496 family protein -
KFU79_RS09055 (1903392) 1903392..1903757 - 366 WP_001280455.1 EutP/PduV family microcompartment system protein -
KFU79_RS09060 (1904028) 1904028..1904417 - 390 WP_077875581.1 transposase -
KFU79_RS09065 (1905215) 1905215..1905295 - 81 Protein_1772 hypothetical protein -
KFU79_RS09070 (1905395) 1905395..1905544 - 150 Protein_1773 DUF5983 family protein -
KFU79_RS09075 (1905541) 1905541..1905918 - 378 WP_042046912.1 TA system toxin CbtA family protein Toxin
KFU79_RS09080 (1906008) 1906008..1906376 - 369 WP_073961352.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU79_RS09085 (1906539) 1906539..1906760 - 222 WP_000692345.1 DUF987 domain-containing protein -
KFU79_RS09090 (1906823) 1906823..1907299 - 477 WP_001186775.1 RadC family protein -
KFU79_RS09095 (1907315) 1907315..1907788 - 474 WP_001350782.1 antirestriction protein -
KFU79_RS09100 (1908130) 1908130..1908948 - 819 WP_001234738.1 DUF932 domain-containing protein -
KFU79_RS09105 (1909066) 1909066..1909261 - 196 Protein_1780 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1899784..1901004 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14020.96 Da        Isoelectric Point: 7.8276

>T200834 WP_042046912.1 NZ_CP073962:c1905918-1905541 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T200834 NZ_CP098183:c2842303-2842052 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13444.17 Da        Isoelectric Point: 6.2050

>AT200834 WP_073961352.1 NZ_CP073962:c1906376-1906008 [Escherichia coli]
VSDTLSGATHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT200834 NZ_CP098183:c2842055-2841801 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References