Detailed information of TA system TA020083

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3741550..3742204
• Replicon: chromosome
• Accession: HG738867
• Organism: Escherichia coli str. K-12 substr. MC4100

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: BN896_2621
• Protein ID: CDJ73944.1
• Coordinates: 3741797..3742204 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: BN896_2622
• Protein ID: CDJ73943.1
• Coordinates: 3741550..3741816 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN896_2627	3736719..3737462	+	744	CDJ73938.1	hypothetical protein	-
BN896_2626	3737519..3738958	-	1440	CDJ73939.1	6-phospho-beta-glucosidase	-
BN896_2625	3738997..3739308	+	312	CDJ73940.1	hypothetical protein	-
BN896_2624	3739472..3740131	+	660	CDJ73941.1	putative oxidoreductase, inner membrane subunit	-
BN896_2623	3740327..3741307	-	981	CDJ73942.1	putative global regulator	-
BN896_2622	3741550..3741816	+	267	CDJ73943.1	hypothetical protein	Antitoxin
BN896_2621	3741797..3742204	+	408	CDJ73944.1	hypothetical protein	Toxin
BN896_2620	3742244..3742765	-	522	CDJ73945.1	flavodoxin FldB	-
BN896_2619	3742877..3743773	+	897	CDJ73946.1	site-specific tyrosine recombinase XerD	-
BN896_2618	3743798..3744508	+	711	CDJ73947.1	thiol:disulfide interchange protein DsbC	-
BN896_2617	3744514..3746247	+	1734	CDJ73948.1	ssDNA exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16031.96 Da
• Isoelectric Point: 11.5202

>T20083 CDJ73944.1 HG738867:3741797-3742204 [Escherichia coli str. K-12 substr. MC4100]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T20083 HG738867:3741797-3742204 [Escherichia coli str. K-12 substr. MC4100]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10547.12 Da
• Isoelectric Point: 5.1599

>AT20083 CDJ73943.1 HG738867:3741550-3741816 [Escherichia coli str. K-12 substr. MC4100]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT20083 HG738867:3741550-3741816 [Escherichia coli str. K-12 substr. MC4100]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA