Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2337114..2337640 | Replicon | chromosome |
| Accession | NZ_CP073958 | ||
| Organism | Escherichia coli strain MB46 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KFU88_RS11595 | Protein ID | WP_000323025.1 |
| Coordinates | 2337353..2337640 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KFU88_RS11590 | Protein ID | WP_000534858.1 |
| Coordinates | 2337114..2337353 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU88_RS11555 (2332377) | 2332377..2332798 | + | 422 | Protein_2260 | hypothetical protein | - |
| KFU88_RS11560 (2333454) | 2333454..2334476 | + | 1023 | Protein_2261 | ISNCY family transposase | - |
| KFU88_RS11565 (2334597) | 2334597..2334746 | + | 150 | WP_011443592.1 | protein YdfW | - |
| KFU88_RS11570 (2335183) | 2335183..2335515 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KFU88_RS11575 (2335718) | 2335718..2335870 | - | 153 | Protein_2264 | hypothetical protein | - |
| KFU88_RS11580 (2335928) | 2335928..2336896 | - | 969 | WP_000654805.1 | IS5-like element IS903B family transposase | - |
| KFU88_RS11585 (2336928) | 2336928..2337089 | - | 162 | Protein_2266 | hypothetical protein | - |
| KFU88_RS11590 (2337114) | 2337114..2337353 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KFU88_RS11595 (2337353) | 2337353..2337640 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KFU88_RS11600 (2337712) | 2337712..2337867 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KFU88_RS11605 (2338084) | 2338084..2338335 | + | 252 | WP_000980994.1 | protein Rem | - |
| KFU88_RS11610 (2338402) | 2338402..2338680 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| KFU88_RS11615 (2338682) | 2338682..2339731 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| KFU88_RS11620 (2339745) | 2339745..2340497 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KFU88_RS11625 (2340775) | 2340775..2340864 | - | 90 | WP_122985911.1 | hypothetical protein | - |
| KFU88_RS11630 (2340919) | 2340919..2341131 | - | 213 | WP_024172454.1 | cold shock-like protein CspF | - |
| KFU88_RS11635 (2341430) | 2341430..2341645 | + | 216 | WP_000066485.1 | cold shock-like protein CspB | - |
| KFU88_RS11640 (2342009) | 2342009..2342179 | - | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| KFU88_RS11645 (2342398) | 2342398..2342613 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2316359..2388901 | 72542 | |
| - | flank | IS/Tn | - | - | 2335928..2336851 | 923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T200817 WP_000323025.1 NZ_CP073958:2337353-2337640 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T200817 NZ_CP098181:50134-50388 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT200817 WP_000534858.1 NZ_CP073958:2337114-2337353 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT200817 NZ_CP098181:50385-50627 [Escherichia coli]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|