Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 802847..803645 Replicon chromosome
Accession NZ_CP073958
Organism Escherichia coli strain MB46

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag KFU88_RS03995 Protein ID WP_000854735.1
Coordinates 802847..803224 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag KFU88_RS04000 Protein ID WP_001285415.1
Coordinates 803271..803645 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU88_RS03965 (798815) 798815..800080 - 1266 WP_025670815.1 integrase arm-type DNA-binding domain-containing protein -
KFU88_RS03970 (800544) 800544..800870 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
KFU88_RS03975 (800867) 800867..801130 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
KFU88_RS03980 (801202) 801202..802068 - 867 WP_001280433.1 DUF4942 domain-containing protein -
KFU88_RS03985 (802153) 802153..802350 - 198 WP_000839291.1 DUF957 domain-containing protein -
KFU88_RS03990 (802362) 802362..802850 - 489 WP_053271890.1 DUF5983 family protein -
KFU88_RS03995 (802847) 802847..803224 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
KFU88_RS04000 (803271) 803271..803645 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU88_RS04005 (803725) 803725..803946 - 222 WP_000692309.1 DUF987 domain-containing protein -
KFU88_RS04010 (804009) 804009..804485 - 477 WP_001366855.1 RadC family protein -
KFU88_RS04015 (804501) 804501..804980 - 480 WP_000844100.1 antirestriction protein -
KFU88_RS04020 (805062) 805062..805880 - 819 WP_001175148.1 DUF932 domain-containing protein -
KFU88_RS04025 (805970) 805970..806203 - 234 WP_001278287.1 DUF905 family protein -
KFU88_RS04030 (806209) 806209..806886 - 678 WP_063100886.1 hypothetical protein -
KFU88_RS04035 (807034) 807034..807714 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 795726..832239 36513
- flank IS/Tn - - 798225..798518 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T200804 WP_000854735.1 NZ_CP073958:c803224-802847 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T200804 NZ_CP098178:c2449267-2448437 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGATCGTTATGATTTTATGAAAT
TCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAGGCTGGCGGCAGT
TATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACATCAGCGATCTCAA
ACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATTTTTTGGCGACAG
CAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCGGCAGCACTGGAT
AACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTTGAGGTTGCATGG
ACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT200804 WP_001285415.1 NZ_CP073958:c803645-803271 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT200804 NZ_CP098178:c2449533-2449267 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References