Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 716572..717407 Replicon chromosome
Accession NZ_CP073958
Organism Escherichia coli strain MB46

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag KFU88_RS03545 Protein ID WP_000854821.1
Coordinates 717030..717407 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KFU88_RS03540 Protein ID WP_072972366.1
Coordinates 716572..716940 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU88_RS03515 (713690) 713690..714508 + 819 WP_001234702.1 DUF932 domain-containing protein -
KFU88_RS03520 (714599) 714599..715084 + 486 WP_000214317.1 antirestriction protein -
KFU88_RS03525 (715099) 715099..715575 + 477 WP_001186773.1 RadC family protein -
KFU88_RS03530 (715638) 715638..715859 + 222 WP_000692353.1 DUF987 domain-containing protein -
KFU88_RS03535 (715878) 715878..716522 + 645 WP_059239987.1 hypothetical protein -
KFU88_RS03540 (716572) 716572..716940 + 369 WP_072972366.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU88_RS03545 (717030) 717030..717407 + 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KFU88_RS03550 (717404) 717404..717892 + 489 WP_059239990.1 DUF5983 family protein -
KFU88_RS03555 (717904) 717904..718101 + 198 WP_000839248.1 DUF957 domain-containing protein -
KFU88_RS03560 (718186) 718186..719031 + 846 WP_049038750.1 DUF4942 domain-containing protein -
KFU88_RS03570 (719331) 719331..719837 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
KFU88_RS03575 (719916) 719916..721757 - 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T200802 WP_000854821.1 NZ_CP073958:717030-717407 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T200802 NZ_CP098178:c2126947-2126840 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.38 Da        Isoelectric Point: 6.2044

>AT200802 WP_072972366.1 NZ_CP073958:716572-716940 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRVGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT200802 NZ_CP098178:2126994-2127060 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54


Antitoxin

Source ID Structure

References