Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 716572..717407 | Replicon | chromosome |
Accession | NZ_CP073958 | ||
Organism | Escherichia coli strain MB46 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A7W4PV54 |
Locus tag | KFU88_RS03545 | Protein ID | WP_000854821.1 |
Coordinates | 717030..717407 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | - |
Locus tag | KFU88_RS03540 | Protein ID | WP_072972366.1 |
Coordinates | 716572..716940 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFU88_RS03515 (713690) | 713690..714508 | + | 819 | WP_001234702.1 | DUF932 domain-containing protein | - |
KFU88_RS03520 (714599) | 714599..715084 | + | 486 | WP_000214317.1 | antirestriction protein | - |
KFU88_RS03525 (715099) | 715099..715575 | + | 477 | WP_001186773.1 | RadC family protein | - |
KFU88_RS03530 (715638) | 715638..715859 | + | 222 | WP_000692353.1 | DUF987 domain-containing protein | - |
KFU88_RS03535 (715878) | 715878..716522 | + | 645 | WP_059239987.1 | hypothetical protein | - |
KFU88_RS03540 (716572) | 716572..716940 | + | 369 | WP_072972366.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
KFU88_RS03545 (717030) | 717030..717407 | + | 378 | WP_000854821.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
KFU88_RS03550 (717404) | 717404..717892 | + | 489 | WP_059239990.1 | DUF5983 family protein | - |
KFU88_RS03555 (717904) | 717904..718101 | + | 198 | WP_000839248.1 | DUF957 domain-containing protein | - |
KFU88_RS03560 (718186) | 718186..719031 | + | 846 | WP_049038750.1 | DUF4942 domain-containing protein | - |
KFU88_RS03570 (719331) | 719331..719837 | + | 507 | WP_000228937.1 | G/U mismatch-specific DNA glycosylase | - |
KFU88_RS03575 (719916) | 719916..721757 | - | 1842 | WP_000437375.1 | RNA polymerase sigma factor RpoD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13930.95 Da Isoelectric Point: 8.5163
>T200802 WP_000854821.1 NZ_CP073958:717030-717407 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T200802 NZ_CP098178:c2126947-2126840 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13623.38 Da Isoelectric Point: 6.2044
>AT200802 WP_072972366.1 NZ_CP073958:716572-716940 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRVGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRVGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT200802 NZ_CP098178:2126994-2127060 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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