Detailed information of TA system
Overview
TA module
| Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
| Location | 4352535..4353032 | Replicon | chromosome |
| Accession | NZ_CP073953 | ||
| Organism | Escherichia coli strain MB49 | ||
Toxin (Protein)
| Gene name | ghoT | Uniprot ID | L4JJG6 |
| Locus tag | KFU90_RS20950 | Protein ID | WP_001173343.1 |
| Coordinates | 4352535..4352708 (-) | Length | 58 a.a. |
Antitoxin (Protein)
| Gene name | ghoS | Uniprot ID | L4JK92 |
| Locus tag | KFU90_RS20955 | Protein ID | WP_000398619.1 |
| Coordinates | 4352736..4353032 (-) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU90_RS20940 (4349205) | 4349205..4350662 | + | 1458 | WP_000856834.1 | dipeptide/tripeptide permease DtpC | - |
| KFU90_RS20945 (4350899) | 4350899..4352416 | + | 1518 | WP_001295074.1 | lysine--tRNA ligase | - |
| KFU90_RS20950 (4352535) | 4352535..4352708 | - | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
| KFU90_RS20955 (4352736) | 4352736..4353032 | - | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
| KFU90_RS20960 (4353259) | 4353259..4353531 | - | 273 | WP_000405647.1 | GNAT family N-acetyltransferase | - |
| KFU90_RS20965 (4353543) | 4353543..4353773 | - | 231 | WP_000371700.1 | 4Fe-4S mono-cluster protein YjdI | - |
| KFU90_RS20970 (4353954) | 4353954..4355585 | + | 1632 | WP_001216486.1 | sensor histidine kinase | - |
| KFU90_RS20975 (4355582) | 4355582..4356301 | + | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4318583..4353032 | 34449 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T200790 WP_001173343.1 NZ_CP073953:c4352708-4352535 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T200790 NZ_CP098175:c3301719-3301617 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 99 a.a. Molecular weight: 11467.97 Da Isoelectric Point: 4.1705
>AT200790 WP_000398619.1 NZ_CP073953:c4353032-4352736 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
Download Length: 297 bp
>AT200790 NZ_CP098175:3301610-3301755 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9QI41 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 2LLZ | |
| AlphaFold DB | A0A7U9QBH6 |