Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 785528..786329 | Replicon | chromosome |
| Accession | NZ_CP073946 | ||
| Organism | Escherichia coli strain MB51 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3W5RL53 |
| Locus tag | KFU68_RS03800 | Protein ID | WP_041124173.1 |
| Coordinates | 785528..785905 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3W5RLB4 |
| Locus tag | KFU68_RS03805 | Protein ID | WP_041124172.1 |
| Coordinates | 785952..786329 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU68_RS03770 (780936) | 780936..781913 | + | 978 | WP_000633209.1 | type II secretion system minor pseudopilin GspK | - |
| KFU68_RS03775 (782099) | 782099..783088 | + | 990 | WP_244599258.1 | type II secretion system protein GspL | - |
| KFU68_RS03780 (783090) | 783090..783625 | + | 536 | Protein_742 | GspM family type II secretion system protein YghD | - |
| KFU68_RS03785 (783907) | 783907..784749 | - | 843 | WP_001280501.1 | DUF4942 domain-containing protein | - |
| KFU68_RS03790 (784834) | 784834..785031 | - | 198 | WP_000838536.1 | DUF957 domain-containing protein | - |
| KFU68_RS03795 (785043) | 785043..785531 | - | 489 | WP_021559503.1 | DUF5983 family protein | - |
| KFU68_RS03800 (785528) | 785528..785905 | - | 378 | WP_041124173.1 | TA system toxin CbtA family protein | Toxin |
| KFU68_RS03805 (785952) | 785952..786329 | - | 378 | WP_041124172.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KFU68_RS03810 (786405) | 786405..786626 | - | 222 | WP_000692307.1 | DUF987 domain-containing protein | - |
| KFU68_RS03815 (786695) | 786695..787171 | - | 477 | WP_021559500.1 | RadC family protein | - |
| KFU68_RS03820 (787187) | 787187..787672 | - | 486 | WP_041124170.1 | antirestriction protein | - |
| KFU68_RS03825 (787764) | 787764..788582 | - | 819 | WP_001234621.1 | DUF932 domain-containing protein | - |
| KFU68_RS03830 (788681) | 788681..788914 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| KFU68_RS03835 (788920) | 788920..789597 | - | 678 | WP_021559490.1 | hypothetical protein | - |
| KFU68_RS03840 (789748) | 789748..790428 | - | 681 | WP_001282912.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM | 774154..823042 | 48888 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13991.90 Da Isoelectric Point: 7.3225
>T200721 WP_041124173.1 NZ_CP073946:c785905-785528 [Escherichia coli]
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
Download Length: 378 bp
>T200721 NZ_CP098159:2534906-2535223 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG
Antitoxin
Download Length: 126 a.a. Molecular weight: 13752.57 Da Isoelectric Point: 6.2021
>AT200721 WP_041124172.1 NZ_CP073946:c786329-785952 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT200721 NZ_CP098159:2535299-2535595 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5RL53 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5RLB4 |