Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1285380..1286005 Replicon chromosome
Accession NZ_CP073943
Organism Escherichia coli strain MB52

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KFU89_RS06230 Protein ID WP_000911330.1
Coordinates 1285607..1286005 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KFU89_RS06225 Protein ID WP_000450524.1
Coordinates 1285380..1285607 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU89_RS06200 (1281182) 1281182..1281652 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KFU89_RS06205 (1281652) 1281652..1282224 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KFU89_RS06210 (1282370) 1282370..1283248 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
KFU89_RS06215 (1283265) 1283265..1284299 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KFU89_RS06220 (1284512) 1284512..1285225 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KFU89_RS06225 (1285380) 1285380..1285607 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KFU89_RS06230 (1285607) 1285607..1286005 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
KFU89_RS06235 (1286152) 1286152..1287015 + 864 WP_001267498.1 neutral zinc metallopeptidase -
KFU89_RS06240 (1287030) 1287030..1289045 + 2016 WP_000829336.1 tRNA cytosine(34) acetyltransferase TmcA -
KFU89_RS06245 (1289119) 1289119..1289817 + 699 WP_000679812.1 esterase -
KFU89_RS06250 (1289927) 1289927..1290127 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T200699 WP_000911330.1 NZ_CP073943:1285607-1286005 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T200699 NZ_CP098145:c4511175-4510765 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT200699 WP_000450524.1 NZ_CP073943:1285380-1285607 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT200699 NZ_CP098145:c4511422-4511156 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References