200697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 867082..867736 Replicon chromosome
Accession NZ_CP073943
Organism Escherichia coli strain MB52

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KFU89_RS04285 Protein ID WP_000244777.1
Coordinates 867329..867736 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KFU89_RS04280 Protein ID WP_000354046.1
Coordinates 867082..867348 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU89_RS04260 (863051) 863051..864484 - 1434 WP_001753034.1 6-phospho-beta-glucosidase BglA -
KFU89_RS04265 (864529) 864529..864840 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
KFU89_RS04270 (865004) 865004..865663 + 660 WP_000250294.1 hemolysin III family protein -
KFU89_RS04275 (865859) 865859..866839 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KFU89_RS04280 (867082) 867082..867348 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KFU89_RS04285 (867329) 867329..867736 + 408 WP_000244777.1 protein YgfX Toxin
KFU89_RS04290 (867776) 867776..868297 - 522 WP_001055874.1 flavodoxin FldB -
KFU89_RS04295 (868409) 868409..869305 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KFU89_RS04300 (869330) 869330..870040 + 711 WP_001753033.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFU89_RS04305 (870046) 870046..871779 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T200697 WP_000244777.1 NZ_CP073943:867329-867736 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T200697 NZ_CP098145:c2906101-2905784 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT200697 WP_000354046.1 NZ_CP073943:867082-867348 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT200697 NZ_CP098145:c2905708-2905412 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References