Detailed information of TA system TA200690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4194781..4195706
• Replicon: chromosome
• Accession: NZ_CP073939
• Organism: Escherichia coli strain MB53

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: KFU83_RS20565
• Protein ID: WP_014640052.1
• Coordinates: 4194781..4195167 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: KFU83_RS20570
• Protein ID: WP_001339382.1
• Coordinates: 4195197..4195706 (-)
• Length: 170 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFU83_RS20525 (4190552)	4190552..4190914	+	363	WP_000135691.1	protein YfdP	-
KFU83_RS20530 (4190980)	4190980..4191804	+	825	WP_001569327.1	DUF2303 family protein	-
KFU83_RS20535 (4191932)	4191932..4192468	+	537	WP_000008210.1	5'-deoxynucleotidase	-
KFU83_RS20540 (4192459)	4192459..4192821	+	363	WP_001565177.1	phage protein	-
KFU83_RS20545 (4192821)	4192821..4193630	+	810	WP_000206745.1	hypothetical protein	-
KFU83_RS20550 (4193630)	4193630..4194202	+	573	WP_001061348.1	3'-5' exonuclease	-
KFU83_RS20555 (4194239)	4194239..4194520	+	282	WP_001093917.1	pyocin activator PrtN family protein	-
KFU83_RS20560 (4194568)	4194568..4194741	-	174	WP_000390072.1	hypothetical protein	-
KFU83_RS20565 (4194781)	4194781..4195167	-	387	WP_014640052.1	hypothetical protein	Toxin
KFU83_RS20570 (4195197)	4195197..4195706	-	510	WP_001339382.1	Panacea domain-containing protein	Antitoxin
KFU83_RS20575 (4196023)	4196023..4196127	-	105	Protein_4027	tRNA-dihydrouridine synthase	-
KFU83_RS20580 (4196490)	4196490..4197511	-	1022	Protein_4028	DUF2713 domain-containing protein	-
KFU83_RS20585 (4197830)	4197830..4198345	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
KFU83_RS20590 (4198387)	4198387..4198596	-	210	WP_001030593.1	CsbD family protein	-
KFU83_RS20595 (4198712)	4198712..4200037	-	1326	WP_001301116.1	MATE family efflux transporter DinF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4141331..4201196	59865

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (6-116)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T200690 WP_014640052.1 NZ_CP073939:c4195167-4194781 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T200690 NZ_CP098145:44914-45297 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 170 a.a.
• Molecular weight: 19576.29 Da
• Isoelectric Point: 5.3338

>AT200690 WP_001339382.1 NZ_CP073939:c4195706-4195197 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Nucleotide

• Length: 510 bp

>AT200690 NZ_CP098145:44672-44914 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA