Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 974889..975472 Replicon chromosome
Accession NZ_CP073939
Organism Escherichia coli strain MB53

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KFU83_RS04805 Protein ID WP_089601808.1
Coordinates 975137..975472 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A161R357
Locus tag KFU83_RS04800 Protein ID WP_040062758.1
Coordinates 974889..975137 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU83_RS04790 (971228) 971228..972529 + 1302 WP_040062759.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
KFU83_RS04795 (972577) 972577..974811 + 2235 WP_000226815.1 GTP pyrophosphokinase -
KFU83_RS04800 (974889) 974889..975137 + 249 WP_040062758.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KFU83_RS04805 (975137) 975137..975472 + 336 WP_089601808.1 endoribonuclease MazF Toxin
KFU83_RS04810 (975543) 975543..976334 + 792 WP_001071643.1 nucleoside triphosphate pyrophosphohydrolase -
KFU83_RS04815 (976562) 976562..978199 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
KFU83_RS04820 (978287) 978287..979585 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-109)

Antitoxin

(2-82)


Sequences


Toxin        


Download         Length: 112 a.a.        Molecular weight: 12142.09 Da        Isoelectric Point: 8.2618

>T200670 WP_089601808.1 NZ_CP073939:975137-975472 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKSSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTLAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T200670 NZ_CP098136:3579741-3580088 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9297.70 Da        Isoelectric Point: 4.5972

>AT200670 WP_040062758.1 NZ_CP073939:974889-975137 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNGITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT200670 NZ_CP098136:3580088-3580387 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A161R357

References