Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1777453..1778284 Replicon chromosome
Accession NZ_CP073936
Organism Escherichia coli strain MB56

Toxin (Protein)


Gene name yeeV Uniprot ID F4THW6
Locus tag KFU61_RS08390 Protein ID WP_000854818.1
Coordinates 1777453..1777827 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag KFU61_RS08395 Protein ID WP_001313071.1
Coordinates 1777916..1778284 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU61_RS08350 (1772849) 1772849..1774015 + 1167 WP_001310935.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
KFU61_RS08355 (1774134) 1774134..1774607 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
KFU61_RS08360 (1774805) 1774805..1775863 + 1059 WP_001200905.1 FUSC family protein -
KFU61_RS08365 (1776035) 1776035..1776364 + 330 WP_000450409.1 DUF496 family protein -
KFU61_RS08370 (1776465) 1776465..1776599 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
KFU61_RS08375 (1776701) 1776701..1776847 + 147 Protein_1634 transposase domain-containing protein -
KFU61_RS08380 (1777136) 1777136..1777216 - 81 Protein_1635 hypothetical protein -
KFU61_RS08385 (1777262) 1777262..1777456 - 195 WP_000988600.1 DUF5983 family protein -
KFU61_RS08390 (1777453) 1777453..1777827 - 375 WP_000854818.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KFU61_RS08395 (1777916) 1777916..1778284 - 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU61_RS08400 (1778364) 1778364..1778585 - 222 WP_000692301.1 DUF987 domain-containing protein -
KFU61_RS08405 (1778648) 1778648..1779124 - 477 WP_001186726.1 RadC family protein -
KFU61_RS08410 (1779140) 1779140..1779619 - 480 WP_000860076.1 antirestriction protein -
KFU61_RS08415 (1779701) 1779701..1780522 - 822 WP_001234530.1 DUF932 domain-containing protein -
KFU61_RS08420 (1780743) 1780743..1781153 - 411 WP_000846713.1 hypothetical protein -
KFU61_RS08425 (1781169) 1781169..1781852 - 684 WP_171931690.1 hypothetical protein -
KFU61_RS08430 (1781988) 1781988..1783058 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13972.98 Da        Isoelectric Point: 7.1333

>T200651 WP_000854818.1 NZ_CP073936:c1777827-1777453 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T200651 NZ_CP098131:2513824-2514171 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT200651 WP_001313071.1 NZ_CP073936:c1778284-1777916 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT200651 NZ_CP098131:2514171-2514470 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W3PHA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References