Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1397815..1398453 Replicon chromosome
Accession HG738867
Organism Escherichia coli str. K-12 substr. MC4100

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BN896_1262 Protein ID CDJ71843.1
Coordinates 1397815..1397991 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BN896_1263 Protein ID CDJ71844.1
Coordinates 1398037..1398453 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN896_1258 1393434..1394609 - 1176 CDJ71839.1 putative benzoate transporter -
BN896_1259 1394701..1395237 + 537 CDJ71840.1 putative DNA-binding transcriptional regulator -
BN896_1260 1395310..1397271 + 1962 CDJ71841.1 putative peptidase -
BN896_1261 1397363..1397593 - 231 CDJ71842.1 hypothetical protein -
BN896_1262 1397815..1397991 + 177 CDJ71843.1 hypothetical protein Toxin
BN896_1263 1398037..1398453 + 417 CDJ71844.1 putative DNA-binding transcriptional regulator Antitoxin
BN896_1264 1398532..1399938 + 1407 CDJ71845.1 fused putative DNA-binding transcriptional regulator/putative amino transferase -
BN896_1265 1400183..1401328 + 1146 CDJ71846.1 putative spermidine/putrescine transporter subunit -
BN896_1266 1401346..1402359 + 1014 CDJ71847.1 putative spermidine/putrescine transporter subunit -
BN896_1267 1402360..1403301 + 942 CDJ71848.1 putative spermidine/putrescine transporter subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T20065 CDJ71843.1 HG738867:1397815-1397991 [Escherichia coli str. K-12 substr. MC4100]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T20065 HG738867:1397815-1397991 [Escherichia coli str. K-12 substr. MC4100]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT20065 CDJ71844.1 HG738867:1398037-1398453 [Escherichia coli str. K-12 substr. MC4100]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT20065 HG738867:1398037-1398453 [Escherichia coli str. K-12 substr. MC4100]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References