Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4198089..4198890 | Replicon | chromosome |
| Accession | NZ_CP073932 | ||
| Organism | Escherichia coli strain MB57 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3W5RL53 |
| Locus tag | KFU62_RS20300 | Protein ID | WP_041124173.1 |
| Coordinates | 4198513..4198890 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3W5RLB4 |
| Locus tag | KFU62_RS20295 | Protein ID | WP_041124172.1 |
| Coordinates | 4198089..4198466 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU62_RS20260 (4193990) | 4193990..4194670 | + | 681 | WP_001282912.1 | WYL domain-containing protein | - |
| KFU62_RS20265 (4194821) | 4194821..4195498 | + | 678 | WP_021559490.1 | hypothetical protein | - |
| KFU62_RS20270 (4195504) | 4195504..4195737 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
| KFU62_RS20275 (4195836) | 4195836..4196654 | + | 819 | WP_001234621.1 | DUF932 domain-containing protein | - |
| KFU62_RS20280 (4196746) | 4196746..4197231 | + | 486 | WP_041124170.1 | antirestriction protein | - |
| KFU62_RS20285 (4197247) | 4197247..4197723 | + | 477 | WP_021559500.1 | RadC family protein | - |
| KFU62_RS20290 (4197792) | 4197792..4198013 | + | 222 | WP_000692307.1 | DUF987 domain-containing protein | - |
| KFU62_RS20295 (4198089) | 4198089..4198466 | + | 378 | WP_041124172.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KFU62_RS20300 (4198513) | 4198513..4198890 | + | 378 | WP_041124173.1 | TA system toxin CbtA family protein | Toxin |
| KFU62_RS20305 (4198887) | 4198887..4199375 | + | 489 | WP_021559503.1 | DUF5983 family protein | - |
| KFU62_RS20310 (4199387) | 4199387..4199584 | + | 198 | WP_000838536.1 | DUF957 domain-containing protein | - |
| KFU62_RS20315 (4199669) | 4199669..4200511 | + | 843 | WP_001280499.1 | DUF4942 domain-containing protein | - |
| KFU62_RS20320 (4201260) | 4201260..4202798 | + | 1539 | WP_001187173.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | papD / papC | 4132902..4210610 | 77708 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13991.90 Da Isoelectric Point: 7.3225
>T200641 WP_041124173.1 NZ_CP073932:4198513-4198890 [Escherichia coli]
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR
Download Length: 378 bp
>T200641 NZ_CP098128:c4398009-4397599 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13752.57 Da Isoelectric Point: 6.2021
>AT200641 WP_041124172.1 NZ_CP073932:4198089-4198466 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT200641 NZ_CP098128:c4398256-4397990 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5RL53 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3W5RLB4 |