Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2405604..2406242 Replicon chromosome
Accession NZ_CP073932
Organism Escherichia coli strain MB57

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag KFU62_RS11605 Protein ID WP_001447010.1
Coordinates 2406066..2406242 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KFU62_RS11600 Protein ID WP_001270286.1
Coordinates 2405604..2406020 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU62_RS11580 (2400756) 2400756..2401697 - 942 WP_001251304.1 ABC transporter permease -
KFU62_RS11585 (2401698) 2401698..2402711 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
KFU62_RS11590 (2402729) 2402729..2403874 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KFU62_RS11595 (2404119) 2404119..2405525 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KFU62_RS11600 (2405604) 2405604..2406020 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KFU62_RS11605 (2406066) 2406066..2406242 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KFU62_RS11610 (2406464) 2406464..2406694 + 231 WP_000494244.1 YncJ family protein -
KFU62_RS11615 (2406786) 2406786..2408747 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KFU62_RS11620 (2408820) 2408820..2409356 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KFU62_RS11625 (2409409) 2409409..2410623 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T200636 WP_001447010.1 NZ_CP073932:c2406242-2406066 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T200636 NZ_CP098128:c1290106-1289888 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT200636 WP_001270286.1 NZ_CP073932:c2406020-2405604 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT200636 NZ_CP098128:c1290507-1290133 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References