Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 94806..95331 Replicon plasmid pYLMB98a
Accession NZ_CP073927
Organism Escherichia coli strain MB98

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag KFU77_RS24060 Protein ID WP_001159871.1
Coordinates 94806..95111 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag KFU77_RS24065 Protein ID WP_000813630.1
Coordinates 95113..95331 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU77_RS24045 (90768) 90768..91934 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
KFU77_RS24050 (92522) 92522..93277 - 756 WP_000852146.1 replication initiation protein RepE -
KFU77_RS24055 (93999) 93999..94805 - 807 WP_000016970.1 site-specific integrase -
KFU77_RS24060 (94806) 94806..95111 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
KFU77_RS24065 (95113) 95113..95331 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
KFU77_RS24070 (95891) 95891..96121 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
KFU77_RS24075 (96118) 96118..96534 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
KFU77_RS24080 (96609) 96609..98174 + 1566 WP_001128474.1 AAA family ATPase -
KFU77_RS24085 (98159) 98159..99181 + 1023 WP_000361402.1 helicase UvrD -
KFU77_RS24090 (99435) 99435..100121 - 687 Protein_120 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / mph(A) / blaCTX-M-15 / aac(3)-IIa / blaOXA-1 / aac(6')-Ib-cr / sitABCD iutA / iucD / iucC / iucB / iucA 1..118380 118380
- flank IS/Tn - - 99435..99782 347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T200591 WP_001159871.1 NZ_CP073927:c95111-94806 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T200591 NZ_CP098030:c3147277-3146879 [Serratia ureilytica]
ATGTTCAGCCATATGCTGGACACCAATATTGTTATCTATGTCATCAAGCGCCGGCCTCTGGAAGTGCTGGAGGCGTTCAA
TCGCTATGCGGGCAAAATGGTCATTTCGTCGGTCACCTATGGCGAATTGGTTCACGGAGTGGAGAAAAGCTCGCGTCCGG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACGGCGCCAAAGCGGCTTCGCACTAC
GGCAACATTCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTGCATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGGTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT200591 WP_000813630.1 NZ_CP073927:c95331-95113 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT200591 NZ_CP098030:c3147510-3147277 [Serratia ureilytica]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACGCAGGCCGTGCGCTTGCCTGCAGAGGTGCGTTTCCCCGATACCGT
TTCTAAAGTGACCGTCCGCGTGGTGGGCAAAGAGCGTATTCTTGCGCCGGTGGAGAATACCTGGGACAGTTTCTTCTGCG
CGGAAAATGAGGTGAGCGATGACTTCCTCAATGAACGTGCCGGGCAACACCAGCGTGAGCGGGAAGCGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References