Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4369460..4369957 Replicon chromosome
Accession NZ_CP073926
Organism Escherichia coli strain MB98

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KFU77_RS21215 Protein ID WP_001173343.1
Coordinates 4369460..4369633 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag KFU77_RS21220 Protein ID WP_001425728.1
Coordinates 4369661..4369957 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU77_RS21205 (4366130) 4366130..4367587 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
KFU77_RS21210 (4367824) 4367824..4369341 + 1518 WP_001295074.1 lysine--tRNA ligase -
KFU77_RS21215 (4369460) 4369460..4369633 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KFU77_RS21220 (4369661) 4369661..4369957 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KFU77_RS21225 (4370184) 4370184..4370456 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
KFU77_RS21230 (4370468) 4370468..4370698 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
KFU77_RS21235 (4370879) 4370879..4372510 + 1632 WP_001216487.1 sensor histidine kinase -
KFU77_RS21240 (4372507) 4372507..4373226 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 papB / papI 4295537..4369957 74420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T200586 WP_001173343.1 NZ_CP073926:c4369633-4369460 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T200586 NZ_CP098030:557213-557563 [Serratia ureilytica]
ATGTGGACGGTAATGACAACGGAAGAGTTTGATCGGTGGCTCTGTGAGCAGGATGAATCGACGCAGGAAAAGGTGTTGGC
CGCGCTGGTGATGCTCGAGCGTGCCGGGCCTTCCCTTCGGCGGCCTTTTGTCGACGTACTGAAAGGCTCGCTGCATCCCA
ACATGAAAGAGCTGCGTATTCAGCACAAAGGGCGGCCGATTCGCGCTTTTTTCGCCTTCGATCCGGCGCGGCAGGCGATT
GTGCTGTGTGCTGGCGACAAAACGGGTAATGAGAAACGGTTTTATAAAGTGATGCTGCCCATCGCAGATGCGCAGTTCAC
CCAATATTTGATGTGTTATTTCAAGGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT200586 WP_001425728.1 NZ_CP073926:c4369957-4369661 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT200586 NZ_CP098030:557567-557866 [Serratia ureilytica]
ATGAGCACCCTAAAGCAACTGCTGGCCTCCCGCTCCCCGGAGAGCCGCCGGCGTATCGAAGAAATGGCCGAAGAGATGCT
GTTTGAAACACACCTGCATCAGCTGCGGGAAGCGTTGAATATTTCCCAACAGGAACTGGCGAAAACGCTGGGCATTTCCC
AGCCTTCGGTCGCGGCCATCGAAGGGCGCGGCAACGAGCTGAAGATTTCGACCCTGAAACGCTACGTGGAAGCGATGGGC
GGCACGCTGCGCCTGGACATTGAACTGCCGGGCGGCAAGCACGTCGGGTTTACGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References