Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4356619..4357417 Replicon chromosome
Accession NZ_CP073926
Organism Escherichia coli strain MB98

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag KFU77_RS21160 Protein ID WP_000854735.1
Coordinates 4357040..4357417 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag KFU77_RS21155 Protein ID WP_032153712.1
Coordinates 4356619..4356993 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU77_RS21120 (4352352) 4352352..4353236 + 885 WP_024166630.1 50S ribosome-binding GTPase -
KFU77_RS21125 (4353355) 4353355..4354032 + 678 WP_023155728.1 hypothetical protein -
KFU77_RS21130 (4354062) 4354062..4354271 + 210 WP_023155727.1 DUF905 family protein -
KFU77_RS21135 (4354362) 4354362..4355180 + 819 WP_001234693.1 DUF932 domain-containing protein -
KFU77_RS21140 (4355272) 4355272..4355757 + 486 WP_032153711.1 antirestriction protein -
KFU77_RS21145 (4355773) 4355773..4356249 + 477 WP_001186715.1 RadC family protein -
KFU77_RS21150 (4356318) 4356318..4356539 + 222 WP_000692345.1 DUF987 domain-containing protein -
KFU77_RS21155 (4356619) 4356619..4356993 + 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
KFU77_RS21160 (4357040) 4357040..4357417 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
KFU77_RS21165 (4357414) 4357414..4357905 + 492 WP_023155722.1 DUF5983 family protein -
KFU77_RS21170 (4357917) 4357917..4358114 + 198 WP_000839265.1 DUF957 domain-containing protein -
KFU77_RS21175 (4358199) 4358199..4359065 + 867 WP_032153714.1 DUF4942 domain-containing protein -
KFU77_RS21180 (4359137) 4359137..4359400 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
KFU77_RS21185 (4359397) 4359397..4359723 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
KFU77_RS21190 (4360606) 4360606..4362144 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 papB / papI 4295537..4369957 74420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T200585 WP_000854735.1 NZ_CP073926:4357040-4357417 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T200585 NZ_CP098030:531304-531693 [Serratia ureilytica]
ATGCAAAAAATATCATCACACCCGATACGGGCGAATCAGCCCTGCCTGTCACCCATTGAAATCTGGCAGCGATTGCTTAC
TCATCTGTTATCGCAGCATTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGACTCCACCATCCAGGAGCATATTG
ATGCCGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGGAAAGAATTGACCGCGATGGTTGC
ACTGTCATGGAAAAGTCACCGTTTATTACCAGTATCGATATTCTACGTGCCCGTAAGGCCTCAGGCCTAATGAAACGCAG
CAGTCACAAAACTGTTACCCGGGTAACGGCAGGCCATCATCAGCAGCTAAAAATCACTAAGGGTACTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT200585 WP_032153712.1 NZ_CP073926:4356619-4356993 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT200585 NZ_CP098030:530900-531265 [Serratia ureilytica]
ATGAATAATCACTCAGAATCCGGTACCACGCCGGAGAATCCTACCTGCCAGCAGTGGGGACTAAAGAGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGACTGCCGGATACATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GTGACAACGATACATTGCGCCTCGACCAAGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTGACTAGCGGCGAG
CTCAATCCCCGCTATCAGCACTGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGTTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References