Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 835725..836559 Replicon chromosome
Accession NZ_CP073926
Organism Escherichia coli strain MB98

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KFU77_RS04070 Protein ID WP_000854727.1
Coordinates 835725..836102 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KFU77_RS04075 Protein ID WP_089613744.1
Coordinates 836191..836559 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU77_RS04035 (830927) 830927..831130 + 204 Protein_792 type II secretion system protein GspJ -
KFU77_RS04040 (831133) 831133..832110 + 978 WP_000633220.1 type II secretion system minor pseudopilin GspK -
KFU77_RS04045 (832107) 832107..833285 + 1179 WP_000094970.1 type II secretion system protein GspL -
KFU77_RS04050 (833287) 833287..833823 + 537 WP_000942786.1 GspM family type II secretion system protein YghD -
KFU77_RS04055 (834104) 834104..834946 - 843 WP_001280501.1 DUF4942 domain-containing protein -
KFU77_RS04060 (835031) 835031..835228 - 198 WP_151293359.1 DUF957 domain-containing protein -
KFU77_RS04065 (835240) 835240..835728 - 489 WP_089613746.1 DUF5983 family protein -
KFU77_RS04070 (835725) 835725..836102 - 378 WP_000854727.1 TA system toxin CbtA family protein Toxin
KFU77_RS04075 (836191) 836191..836559 - 369 WP_089613744.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU77_RS04080 (836639) 836639..836860 - 222 WP_000692323.1 DUF987 domain-containing protein -
KFU77_RS04085 (836923) 836923..837399 - 477 WP_074503008.1 RadC family protein -
KFU77_RS04090 (837415) 837415..837900 - 486 WP_000206660.1 antirestriction protein -
KFU77_RS04095 (837992) 837992..838810 - 819 WP_001234693.1 DUF932 domain-containing protein -
KFU77_RS04100 (838909) 838909..839142 - 234 WP_001278281.1 DUF905 family protein -
KFU77_RS04105 (839148) 839148..839825 - 678 WP_053291273.1 hypothetical protein -
KFU77_RS04110 (839944) 839944..840828 - 885 WP_053291272.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspK / gspL / gspM 822999..850968 27969


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14345.39 Da        Isoelectric Point: 9.2442

>T200568 WP_000854727.1 NZ_CP073926:c836102-835725 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T200568 NZ_CP097984:1475695-1476105 [Pimelobacter simplex]
ATGACCGACTGGCTCATCGACAAGTCCGCCCTCGTCCGGCTGGCGCACGCTGCCGAGCGCGACGAGTGGCGCGAGCGCTG
CCGCCGGGGTCTGGTCCGGATCACCTCGCCGACGCTGCTCGAGGCGGGCTTCTCCGCACGATCGGCCGACGACTGGCAGG
CGCTGGTCGCCGGTCCGCCCGTGTCGTGGTTCCCCGTCGAGTACCTCACCCCCGCCATCGAGCGCCGTGCGCTCGACGTC
CAGCGCATCCTCGCGGCGCGTGGCCAGCACCGCGCCCCGTCGGTGCCCGACCTGCTGATCGCCGCGACGGCCGAGCTGGC
GGGGCTCGTCGTCCTCCACCTCGACAAGGACTTCGAGCTCATCGCCGACGTCACCGGTCAGCAGGTCGAGCGCCTCGGCC
TCACTGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13648.42 Da        Isoelectric Point: 7.7474

>AT200568 WP_089613744.1 NZ_CP073926:c836559-836191 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQESNQLHYLANRAGIRGRFSDADAYHLDQTFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT200568 NZ_CP097984:1475471-1475698 [Pimelobacter simplex]
ATGACTGACCTGCTCATTCGGAACGTGCCCGACGAGGACCTGCGGCGGATCGACGACAAGGCTCGTCGGCTCGGCCTGTC
ACGGGCCGACTACTTCCGTCGGCTGATCCTCCAGGAGGCGGCGCGCGGGGTCGACGACGCCGAACCGGGCACCGACGTCT
TCGCGCGGTTCGCGGACCTCGCCCAGGACCTCGGCGACGACGACGTCATGAGGGACGCCTGGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References