Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 344675..345475 Replicon chromosome
Accession NZ_CP073926
Organism Escherichia coli strain MB98

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag KFU77_RS01610 Protein ID WP_000342449.1
Coordinates 344948..345475 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag KFU77_RS01605 Protein ID WP_001277108.1
Coordinates 344675..344941 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU77_RS01585 (340332) 340332..341000 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
KFU77_RS01590 (340993) 340993..342051 + 1059 WP_130560548.1 permease-like cell division protein FtsX -
KFU77_RS01595 (342296) 342296..343150 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
KFU77_RS01600 (343422) 343422..344525 + 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
KFU77_RS01605 (344675) 344675..344941 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
KFU77_RS01610 (344948) 344948..345475 + 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
KFU77_RS01615 (345472) 345472..345855 - 384 WP_000778781.1 aspartate 1-decarboxylase autocleavage activator PanM -
KFU77_RS01620 (346279) 346279..347388 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
KFU77_RS01625 (347436) 347436..348362 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KFU77_RS01630 (348359) 348359..349636 + 1278 WP_000803799.1 branched chain amino acid ABC transporter permease LivM -
KFU77_RS01635 (349633) 349633..350400 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T200565 WP_000342449.1 NZ_CP073926:344948-345475 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T200565 NZ_CP097983:c1448113-1447802 [Pantoea alhagi]
ATGCATATTATTACGAGGGAGCCCTTTGATAAAGCTGCAAAGCTTTTTCCCAACCATGCTTTAGCGCTTGATGACTTATA
TCGCCACTTAAAGCGGGTGAGGTTTACCAGCCCGGAAGATCTTAAAAAAACCTTCCCCAGCCTGGACAGAATGAAGTACC
GCGAAAAATGGTGGGTAATCGATATAGGGGGCGGCAATCTGCGCGTCATGTTCTTTGCAGATTTTGAGCAAGGGAAGATC
TTTATAAAGCATATAGCTACTCACGCAGAATACGATAAGTTGACTGACTTTTATCGGAGAAACAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT200565 WP_001277108.1 NZ_CP073926:344675-344941 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT200565 NZ_CP097983:c1447805-1447389 [Pantoea alhagi]
ATGATTTTTAGCGACGCAATTGAGGCAGCAGATAGTCTGGTGAGAATTCTCCCTCTGTTAGGAGGCAGCACTTGCCGTAA
AGACTATGAAGAAGCGGTCAGGCTGGTGGAATATCTGGTGGAGCATCAACCAGACAGCCCGCTCATCGAAATGCTGACAG
CGAAAATTGATGCTTATGAAAACAATGCACCAGAATTTGCCGAGTTTAATGCACGTATTGATACCGAGCCGCATGGCGTA
TCGTTATTACGTATTTTGATGGATCAATATGGACTTAATCAGACCGACTTTGTAAAAGAGATTGGTCAGCGTTCGCTGGT
AAGCCGCATATTAAAAGGCGAGCGTAAGCTGACGCTGGAACATATGCGTAACCTGGCTAAACGCTTTAACATCCCGGTAA
GCCGCTTCGTCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References