Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4233799..4234394 Replicon chromosome
Accession NZ_CP073924
Organism Escherichia coli strain MB165

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KFU71_RS20355 Protein ID WP_000239579.1
Coordinates 4233799..4234149 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KFU71_RS20360 Protein ID WP_001223208.1
Coordinates 4234143..4234394 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU71_RS20335 (4229245) 4229245..4230267 - 1023 WP_001368084.1 ABC transporter permease -
KFU71_RS20340 (4230281) 4230281..4231783 - 1503 WP_000210554.1 sugar ABC transporter ATP-binding protein -
KFU71_RS20345 (4231923) 4231923..4232879 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KFU71_RS20350 (4233189) 4233189..4233719 + 531 WP_000055075.1 inorganic diphosphatase -
KFU71_RS20355 (4233799) 4233799..4234149 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KFU71_RS20360 (4234143) 4234143..4234394 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KFU71_RS20365 (4234606) 4234606..4234947 - 342 WP_257187637.1 gamma-glutamylcyclotransferase -
KFU71_RS20370 (4234950) 4234950..4238729 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T200561 WP_000239579.1 NZ_CP073924:c4234149-4233799 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T200561 NZ_CP097983:594333-594674 [Pantoea alhagi]
ATGAAAACTTTACCTGCATCAACTCAGCGGGCGGCTAAGCCATGCCCGACGCCCGTAGTTGTCTGGCAAACGCTACTCAC
CCGTCTGCTGGAGCAACACTATGGTCTGACTCTGAACGACACGCCATTCTGCGATGAAACAGTCATTCAGGAACATATTA
ACGCCGGTATCACACTGGCTGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGATTCGTATCGATCGCAGAGGGTTT
AGCTGGCAGGAACAATCGCCTTATCTTCGGGCTGTAGATATTTTGCGGGCGAGACAGGCAACTGGTCTGTTACGACAAAG
CCATAATCTTTCGACACGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT200561 WP_001223208.1 NZ_CP073924:c4234394-4234143 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT200561 NZ_CP097983:593971-594297 [Pantoea alhagi]
ATGGAGAAAAACGATCCCATCGAATGGGGGCTTCGACGCGATATCACGCCGCGTGTAGGAGCAAGACTGGTACAGGAAGG
AAATCAATTGCATTACCTGGTTGGCCGGGCCGGTGTCACCGGCATTTTTAATGAAGCTGAGAGCCGCAAACTGAATGCAG
CATTTCCGCATTTCGTGGAGCAGATGGAGTTAATGCTACTCTCCGGGGAACTAAACCCCCGTTATGCACATTGTGTCACC
CTGTACCATGATGGATTTACCTGTGAAGCTGACACGCTTGGCTCTTATGGTTACGTCTACATCGTCATTTACCCCACTCA
ACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References