Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4133299..4134134 | Replicon | chromosome |
| Accession | NZ_CP073924 | ||
| Organism | Escherichia coli strain MB165 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2S4A272 |
| Locus tag | KFU71_RS19835 | Protein ID | WP_001094443.1 |
| Coordinates | 4133299..4133676 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7LDN9 |
| Locus tag | KFU71_RS19840 | Protein ID | WP_001285607.1 |
| Coordinates | 4133766..4134134 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU71_RS19805 (4128430) | 4128430..4128972 | + | 543 | WP_001115385.1 | hypothetical protein | - |
| KFU71_RS19810 (4128969) | 4128969..4130438 | + | 1470 | WP_001022619.1 | serine/threonine-protein kinase | - |
| KFU71_RS19815 (4130639) | 4130639..4131904 | - | 1266 | WP_001218329.1 | integrase arm-type DNA-binding domain-containing protein | - |
| KFU71_RS19820 (4132369) | 4132369..4132512 | - | 144 | Protein_3877 | hypothetical protein | - |
| KFU71_RS19825 (4132597) | 4132597..4132794 | - | 198 | WP_001327226.1 | DUF957 domain-containing protein | - |
| KFU71_RS19830 (4132814) | 4132814..4133302 | - | 489 | WP_000761685.1 | DUF5983 family protein | - |
| KFU71_RS19835 (4133299) | 4133299..4133676 | - | 378 | WP_001094443.1 | TA system toxin CbtA family protein | Toxin |
| KFU71_RS19840 (4133766) | 4133766..4134134 | - | 369 | WP_001285607.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KFU71_RS19845 (4134214) | 4134214..4134435 | - | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| KFU71_RS19850 (4134522) | 4134522..4134998 | - | 477 | WP_001186165.1 | RadC family protein | - |
| KFU71_RS19855 (4135013) | 4135013..4135498 | - | 486 | WP_000206664.1 | antirestriction protein | - |
| KFU71_RS19860 (4135590) | 4135590..4136408 | - | 819 | WP_001175163.1 | DUF932 domain-containing protein | - |
| KFU71_RS19865 (4136498) | 4136498..4136731 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| KFU71_RS19870 (4136737) | 4136737..4137414 | - | 678 | WP_001097301.1 | hypothetical protein | - |
| KFU71_RS19875 (4137562) | 4137562..4138242 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(B) | fimC / fimI / fimA / fimE / fimB | 4102009..4179303 | 77294 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14058.97 Da Isoelectric Point: 7.3523
>T200560 WP_001094443.1 NZ_CP073924:c4133676-4133299 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T200560 NZ_CP097897:c2965144-2964779 [Acetobacterium wieringae]
ATGTATGAAGTAATTTTTTATAAAGACGCAAAGGGTAATGAGCCGATCAGGGAATACCTCACCAGTTTAAAAACCAAAGC
CAGTAGCAGTAAGCAAAATCGTGTTAAATTTATAAAAATCACTAGTTACATACGATCGTTACAGGAATATGGCACAAGAA
TTGGCAATCCCACCGTTAAGCATATTGATGGCGATATCTGGGAACTCCGGCCCTTATCAGATCGGATATTTTTCTTTTAT
TGGCAAGATGATACGTTTGTTTTGCTTCACTATTTCCATAAGAAGTCGCAAAAGATACCGCGAAAGGAAATTGAAAAAGC
AATCAATAATATGAATGATTTTAAAGAAAGGGTGTGCCAGCAATGA
ATGTATGAAGTAATTTTTTATAAAGACGCAAAGGGTAATGAGCCGATCAGGGAATACCTCACCAGTTTAAAAACCAAAGC
CAGTAGCAGTAAGCAAAATCGTGTTAAATTTATAAAAATCACTAGTTACATACGATCGTTACAGGAATATGGCACAAGAA
TTGGCAATCCCACCGTTAAGCATATTGATGGCGATATCTGGGAACTCCGGCCCTTATCAGATCGGATATTTTTCTTTTAT
TGGCAAGATGATACGTTTGTTTTGCTTCACTATTTCCATAAGAAGTCGCAAAAGATACCGCGAAAGGAAATTGAAAAAGC
AATCAATAATATGAATGATTTTAAAGAAAGGGTGTGCCAGCAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13689.53 Da Isoelectric Point: 6.4669
>AT200560 WP_001285607.1 NZ_CP073924:c4134134-4133766 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT200560 NZ_CP097897:c2964782-2964471 [Acetobacterium wieringae]
ATGAGTATTAAAATTGGCAATGAAGAATTTACAGAATTCAATGATCTTTATAATGACTCTGATTTCTTGAGCGATTCAGA
AAGGGCAGAAATTGAATTTGAGGTAGCGCTGATCGGCAAACTGATCGAAGCCCGTGAGCAGTGTGGAATGTCACAAAAAC
AACTCGCTGATCTGACTGGATTAAAACAACCGGCCATCGCACGTCTGGAGAATCTCAAAGCCATTCCCAAAATTGATACC
CTGTTTAAGCTTCTTGACCCGCTGGGGTATACATTGGCGATTGTACCCAAAGAGAAAACGATTGTGAAATAA
ATGAGTATTAAAATTGGCAATGAAGAATTTACAGAATTCAATGATCTTTATAATGACTCTGATTTCTTGAGCGATTCAGA
AAGGGCAGAAATTGAATTTGAGGTAGCGCTGATCGGCAAACTGATCGAAGCCCGTGAGCAGTGTGGAATGTCACAAAAAC
AACTCGCTGATCTGACTGGATTAAAACAACCGGCCATCGCACGTCTGGAGAATCTCAAAGCCATTCCCAAAATTGATACC
CTGTTTAAGCTTCTTGACCCGCTGGGGTATACATTGGCGATTGTACCCAAAGAGAAAACGATTGTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2S4A272 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0JLU8 |