Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3501127..3501745 Replicon chromosome
Accession NZ_CP073924
Organism Escherichia coli strain MB165

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFU71_RS16875 Protein ID WP_001291435.1
Coordinates 3501527..3501745 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag KFU71_RS16870 Protein ID WP_000344794.1
Coordinates 3501127..3501501 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU71_RS16860 (3496216) 3496216..3497409 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFU71_RS16865 (3497432) 3497432..3500581 + 3150 WP_001132470.1 efflux RND transporter permease AcrB -
KFU71_RS16870 (3501127) 3501127..3501501 + 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
KFU71_RS16875 (3501527) 3501527..3501745 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFU71_RS16880 (3501916) 3501916..3502467 + 552 WP_000102564.1 maltose O-acetyltransferase -
KFU71_RS16885 (3502583) 3502583..3503053 + 471 WP_000136192.1 YlaC family protein -
KFU71_RS16890 (3503217) 3503217..3504767 + 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFU71_RS16895 (3504809) 3504809..3505162 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KFU71_RS16905 (3505541) 3505541..3505852 + 312 WP_000409911.1 MGMT family protein -
KFU71_RS16910 (3505883) 3505883..3506455 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T200557 WP_001291435.1 NZ_CP073924:3501527-3501745 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T200557 NZ_CP097896:c3646506-3646192 [Pectobacterium actinidiae]
ATGCAATTCACTGTATACGGTAATACCGGGAAAAGCGTCGTTTATCCACTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAATTGAATCGTCGGATAGTGATCCCATTGCTCCCTATTGAAAAGTATCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCGGTAATGACCCACGAACTAGCAAGTATCCCTGTCCAGGCTCTGGGG
GCGGTGTTTTGCGATGCGTCGCAGTACCGCACTCAGGTAAAGGCTGCAATAGACTTCCTCATCGACGGGTTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT200557 WP_000344794.1 NZ_CP073924:3501127-3501501 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT200557 NZ_CP097896:c3646745-3646509 [Pectobacterium actinidiae]
ATGACCGCGAAACCACGCAACACGCAGAGCGTGACCATGACAGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGAAGCGGG
TATTAATCTGAGTGCTACTCTGACAACCGCCCTGGATGCAGAACTTCGCTATCATGAAGCGAAAAAATGGCAGGAAGAAA
ACAGGGAGGCTCTCGCAGCACTCAATCGTTTTCATGATGAGCAGGGTTGTTTCAGCGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References