Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2440293..2441881 Replicon chromosome
Accession NZ_CP073924
Organism Escherichia coli strain MB165

Toxin (Protein)


Gene name hipA Uniprot ID E9TB78
Locus tag KFU71_RS11900 Protein ID WP_001125466.1
Coordinates 2440559..2441881 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KFU71_RS11895 Protein ID WP_001296726.1
Coordinates 2440293..2440559 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU71_RS11895 (2440293) 2440293..2440559 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KFU71_RS11900 (2440559) 2440559..2441881 + 1323 WP_001125466.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
KFU71_RS11905 (2442193) 2442193..2442401 + 209 Protein_2328 AraC family transcriptional regulator -
KFU71_RS11910 (2442835) 2442835..2443398 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
KFU71_RS11915 (2443759) 2443759..2444469 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2440293..2456382 16089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49438.05 Da        Isoelectric Point: 9.1005

>T200555 WP_001125466.1 NZ_CP073924:2440559-2441881 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHYLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T200555 NZ_CP097896:c2072856-2072437 [Pectobacterium actinidiae]
ATGATAGATATCTTGCTCAACAAAAGCACCACCATACAAAGATGCCTACGTCGTATTCGTGAAGAATTCGATACTGAGGA
AGGATTTCGTCAAAACTTCACCAAGCAAGATTCCGTCATACTTAACATACAGCGTGCCTGCGAAGCCGCTATTGATATCG
CTAATTATCTTATCCGTATCAAGCAGCTAGGCATACCACAAAGTAGCCGCGATAGCTTCGCGCTTCTTGCTGCAAACCAG
ATTATTACGATTGATCTGTCTGATAATTTGCAAAAAATGGTGGGATTAAGAAATATTGCCGTGCATGACTATCAGGCGCT
CAATCTGGATATTGTCATCCACGTCATTTCTCATCGTTTAAGCGACTTTGAACATTTTATCAAACAAATAGCACGGTACA
GCGACAGCCAGCACCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT200555 WP_001296726.1 NZ_CP073924:2440293-2440559 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp

>AT200555 NZ_CP097896:c2073236-2072853 [Pectobacterium actinidiae]
ATGTTCGATAAGATCGTTTTGACACTGAAAAAACAGATGCCCGACATCAAAATTATTTATCTCTTTGGTTCCCAAGCTAC
AGGCAATGCCAGAGCGGACAGCGACATTGATATCGCCATCATGGCTACAAGAGCACTGGATCCCGTTGAACGCTGGGAGC
TATCTAATCAATTAGCAAAGGAAGTGGGTCATGACGTCGATCTTATCGATTTATTGCAGGCTTCAACGGTATTAAAAATG
GAGATCGTTCGTAACGGCAAGCTGCTTTATGATGCGGAAACAGCAGCGGGGGAATTTGAAATGACAACACTTTCGATGTA
CCAGCATCTGCAAAAAGAGCGCGCGGATATCATTCGTAGCTTTAATCAGGATCTAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References