Detailed information of TA system TA020055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 382073..382691
• Replicon: chromosome
• Accession: HG738867
• Organism: Escherichia coli str. K-12 substr. MC4100

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: BN896_0341
• Protein ID: CDJ70929.1
• Coordinates: 382073..382291 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: BN896_0342
• Protein ID: CDJ70930.1
• Coordinates: 382317..382691 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN896_0335	377362..377934	+	573	CDJ70923.1	putative outer membrane lipoprotein	-
BN896_0336	377965..378354	-	390	CDJ70924.1	putative methyltransferase	-
BN896_0337	378655..379008	+	354	CDJ70925.1	hypothetical protein	-
BN896_0338	379050..380600	-	1551	CDJ70926.1	hypothetical protein	-
BN896_0339	380764..381234	-	471	CDJ70927.1	putative inner membrane protein	-
BN896_0340	381350..381901	-	552	CDJ70928.1	maltose O-acetyltransferase	-
BN896_0341	382073..382291	-	219	CDJ70929.1	hemolysin expression-modulating protein	Toxin
BN896_0342	382317..382691	-	375	CDJ70930.1	hypothetical protein	Antitoxin
BN896_0343	383237..386386	-	3150	CDJ70931.1	multidrug efflux system protein	-
BN896_0344	386409..387602	-	1194	CDJ70932.1	multidrug efflux system	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8678.06 Da
• Isoelectric Point: 8.9008

>T20055 CDJ70929.1 HG738867:c382291-382073 [Escherichia coli str. K-12 substr. MC4100]
MSEKFLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T20055 HG738867:c382291-382073 [Escherichia coli str. K-12 substr. MC4100]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14557.39 Da
• Isoelectric Point: 4.7395

>AT20055 CDJ70930.1 HG738867:c382691-382317 [Escherichia coli str. K-12 substr. MC4100]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Nucleotide

• Length: 375 bp

>AT20055 HG738867:c382691-382317 [Escherichia coli str. K-12 substr. MC4100]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG