Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 802756..803554 Replicon chromosome
Accession NZ_CP073924
Organism Escherichia coli strain MB165

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag KFU71_RS03880 Protein ID WP_000854735.1
Coordinates 802756..803133 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag KFU71_RS03885 Protein ID WP_001285415.1
Coordinates 803180..803554 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU71_RS03850 (798164) 798164..799141 + 978 WP_000633222.1 type II secretion system minor pseudopilin GspK -
KFU71_RS03855 (799138) 799138..800316 + 1179 WP_000094974.1 type II secretion system protein GspL -
KFU71_RS03860 (800318) 800318..800854 + 537 WP_000942786.1 GspM family type II secretion system protein YghD -
KFU71_RS03865 (801135) 801135..801977 - 843 WP_001290191.1 DUF4942 domain-containing protein -
KFU71_RS03870 (802062) 802062..802259 - 198 WP_000839291.1 DUF957 domain-containing protein -
KFU71_RS03875 (802271) 802271..802759 - 489 WP_257187643.1 DUF5983 family protein -
KFU71_RS03880 (802756) 802756..803133 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
KFU71_RS03885 (803180) 803180..803554 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KFU71_RS03890 (803634) 803634..803855 - 222 WP_000692309.1 DUF987 domain-containing protein -
KFU71_RS03895 (803918) 803918..804394 - 477 WP_001366855.1 RadC family protein -
KFU71_RS03900 (804410) 804410..804889 - 480 WP_000844100.1 antirestriction protein -
KFU71_RS03905 (804971) 804971..805789 - 819 WP_001175149.1 DUF932 domain-containing protein -
KFU71_RS03910 (805879) 805879..806112 - 234 WP_001278287.1 DUF905 family protein -
KFU71_RS03915 (806118) 806118..806795 - 678 WP_001097301.1 hypothetical protein -
KFU71_RS03920 (806943) 806943..807623 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM 776999..818074 41075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T200542 WP_000854735.1 NZ_CP073924:c803133-802756 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T200542 NZ_CP097895:c1272575-1271829 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
AGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGGAGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGGACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT200542 WP_001285415.1 NZ_CP073924:c803554-803180 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT200542 NZ_CP097895:c1271828-1271658 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References