Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 291983..292614 | Replicon | chromosome |
Accession | NZ_CP073924 | ||
Organism | Escherichia coli strain MB165 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | F4NNK6 |
Locus tag | KFU71_RS01315 | Protein ID | WP_001259388.1 |
Coordinates | 291983..292258 (+) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | KFU71_RS01320 | Protein ID | WP_000593555.1 |
Coordinates | 292255..292614 (+) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFU71_RS01300 (286987) | 286987..288054 | + | 1068 | WP_000361482.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
KFU71_RS01305 (288051) | 288051..290786 | + | 2736 | WP_000149132.1 | ribosome-associated ATPase/putative transporter RbbA | - |
KFU71_RS01310 (290786) | 290786..291910 | + | 1125 | WP_001615305.1 | ABC transporter permease | - |
KFU71_RS01315 (291983) | 291983..292258 | + | 276 | WP_001259388.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
KFU71_RS01320 (292255) | 292255..292614 | + | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
KFU71_RS01325 (292734) | 292734..293135 | - | 402 | WP_001190064.1 | nickel-responsive transcriptional regulator NikR | - |
KFU71_RS01330 (293141) | 293141..293947 | - | 807 | WP_000173666.1 | nickel import ATP-binding protein NikE | - |
KFU71_RS01335 (293944) | 293944..294708 | - | 765 | WP_001136236.1 | nickel import ATP-binding protein NikD | - |
KFU71_RS01340 (294708) | 294708..295541 | - | 834 | WP_112014838.1 | nickel ABC transporter permease subunit NikC | - |
KFU71_RS01345 (295538) | 295538..296482 | - | 945 | WP_000947068.1 | nickel ABC transporter permease subunit NikB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 274282..292614 | 18332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10151.89 Da Isoelectric Point: 10.7076
>T200540 WP_001259388.1 NZ_CP073924:291983-292258 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
Download Length: 276 bp
>T200540 NZ_CP097887:914776-915132 [Staphylococcus arlettae]
ATGAGACGAGGAGACGTCTACTTAGCTGACTTATCACCAGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGTAAT
TATTCAAAATGATACTGGTAATAAATATAGTCCTACCGTGATTGTAGCTGCAATCACTGGTAGGATAAATAAAGCTAAAA
TACCAACACATGTTGAAATTGAAAAGAAAAAGTATAAATTGGATAAGGATTCAGTTATATTACTTGAGCAGATTCGAACG
TTAGATAAAAAAAGATTAAAAGAAAAGTTAACATACTTATCAGAAGATAAAATGAAAGAAGTCAACATAGCAATTGACAT
AAGTTTAGGATTACATAATAATAGGCATCATAAGTAA
ATGAGACGAGGAGACGTCTACTTAGCTGACTTATCACCAGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGTAAT
TATTCAAAATGATACTGGTAATAAATATAGTCCTACCGTGATTGTAGCTGCAATCACTGGTAGGATAAATAAAGCTAAAA
TACCAACACATGTTGAAATTGAAAAGAAAAAGTATAAATTGGATAAGGATTCAGTTATATTACTTGAGCAGATTCGAACG
TTAGATAAAAAAAGATTAAAAGAAAAGTTAACATACTTATCAGAAGATAAAATGAAAGAAGTCAACATAGCAATTGACAT
AAGTTTAGGATTACATAATAATAGGCATCATAAGTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13402.27 Da Isoelectric Point: 5.1987
>AT200540 WP_000593555.1 NZ_CP073924:292255-292614 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
Download Length: 360 bp
>AT200540 NZ_CP097887:914606-914776 [Staphylococcus arlettae]
ATGCCAAGTTTTAACCAAAGTAGAAATCATAACATAGAACAATCTTTAAAAGAAGGCTATTCCCAAATGGCTGATTTGAA
TCTCTCCCTTGCAGCAGAAGCTTTTCCATTCGAATGTGAAGCTTGTGATTGCAACGAATCATATATTAGTGCTAGTAACA
CTAATGACTAA
ATGCCAAGTTTTAACCAAAGTAGAAATCATAACATAGAACAATCTTTAAAAGAAGGCTATTCCCAAATGGCTGATTTGAA
TCTCTCCCTTGCAGCAGAAGCTTTTCCATTCGAATGTGAAGCTTGTGATTGCAACGAATCATATATTAGTGCTAGTAACA
CTAATGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0A0FFA2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |